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Parp3 Gene Detail
Summary
  • Symbol
    Parp3
  • Name
    poly (ADP-ribose) polymerase family, member 3
  • Synonyms
    A930002C11Rik, Adprt3, Adprtl3, PARP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891258
    NCBI Gene: 235587
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106347521-106354148 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 57.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891258
 protein coding gene Chr9:106347521-106354148 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035234
 protein coding gene Chr9:108281446-108291135 (-)
A/J MGP_AJ_G0035213
 protein coding gene Chr9:104366598-104373219 (-)
AKR/J MGP_AKRJ_G0035145
 protein coding gene Chr9:106968740-106975369 (-)
BALB/cJ MGP_BALBcJ_G0035207
 protein coding gene Chr9:104052239-104058855 (-)
C3H/HeJ MGP_C3HHeJ_G0034917
 protein coding gene Chr9:107382574-107389226 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035727
 protein coding gene Chr9:111266140-111272742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032625
 protein coding gene Chr9:101856966-101863741 (-)
CAST/EiJ MGP_CASTEiJ_G0034228
 protein coding gene Chr9:107287503-107294182 (-)
CBA/J MGP_CBAJ_G0034885
 protein coding gene Chr9:115199279-115205884 (-)
DBA/2J MGP_DBA2J_G0035046
 protein coding gene Chr9:103829275-103835918 (-)
FVB/NJ MGP_FVBNJ_G0034994
 protein coding gene Chr9:102608449-102615419 (-)
LP/J MGP_LPJ_G0035122
 protein coding gene Chr9:108501862-108508458 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035033
 protein coding gene Chr9:116792191-116799775 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035748
 protein coding gene Chr9:107219224-107227150 (-)
PWK/PhJ MGP_PWKPhJ_G0033935
 protein coding gene Chr9:104128239-104134909 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033770
 protein coding gene Chr9:107289463-107296016 (-)
WSB/EiJ MGP_WSBEiJ_G0034349
 protein coding gene Chr9:107115440-107122094 (-)



Homology
more
  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARP3, poly(ADP-ribose) polymerase family member 3
  • Synonyms
    ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3
  • Links
    NCBI Gene ID: 10039
    neXtProt AC: NX_Q9Y6F1
    UniProt: Q9Y6F1

  • Chr Location
    3p21.2; chr3:51942345-51948867 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Mice homozygous for a knock-out allele exhibit normal survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    39
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 235587 NCBI Gene Model | MGI Sequence Detail 6628 C57BL/6J ±  kb
transcript NM_001311150 RefSeq | MGI Sequence Detail 2977 C57BL/6  
polypeptide Q3ULW8 UniProt | EBI | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 5
Other
Accession IDs
less
MGI:2143354, MGI:2444599
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:79987 Urbanek P, et al., Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9. Folia Biol (Praha). 2002;48(5):182-91
  • Latest
    J:340875 Zhou Z, et al., Fance deficiency inhibits primordial germ cell proliferation associated with transcription-replication conflicts accumulate and DNA repair defects. J Ovarian Res. 2023 Aug 10;16(1):160
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory