Nidd5 QTL Detail

Summary

• Symbol
  Nidd5
• Name
  non-insulin-dependent diabetes mellitus 5

• Feature Type
  QTL
• IDs
  MGI:1891280
  NCBI Gene: 112358
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, 31.66 cM (cM position of peak correlated region/marker)
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotypes from 2 alleles in 2 genetic backgrounds
  5 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  1 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112358

References

• Summaries
  All 8

  Phenotypes 5
• Earliest
  J:55285 Hirayama I, et al., Genetic analysis of obese diabetes in the TSOD mouse. Diabetes. 1999 May;48(5):1183-91
• Latest
  J:208486 Yogosawa S, et al., Activin receptor-like kinase 7 suppresses lipolysis to accumulate fat in obesity through downregulation of peroxisome proliferator-activated receptor gamma and C/EBPalpha. Diabetes. 2013 Jan;62(1):115-23

Candidate Genes for Nidd5:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Nek6	Chr2:38401655-38484618 (+)	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 2, Nek6 showed differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Nidd5 (34.5 cM) maps near this candidate gene.