Lpin2 MGI Mouse Gene Detail - MGI:1891341

Symbol

Lpin2
Name

lipin 2
Synonyms

2610511G02Rik

Feature Type

protein coding gene
IDs

MGI:1891341
NCBI Gene: 64898
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr17:71490527-71556813 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 41.87 cM
Mapping Data

3 experiments

SNPs within 2kb

1872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891341	protein coding gene	Chr17:71489555-71556813 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024005	protein coding gene	Chr17:73616048-73686027 (+)
A/J	MGP_AJ_G0023963	protein coding gene	Chr17:71381711-71457305 (+)
AKR/J	MGP_AKRJ_G0023932	protein coding gene	Chr17:72355879-72422615 (+)
BALB/cJ	MGP_BALBcJ_G0023964	protein coding gene	Chr17:71288942-71356730 (+)
C3H/HeJ	MGP_C3HHeJ_G0023728	protein coding gene	Chr17:73311135-73381887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024410	protein coding gene	Chr17:76299546-76371339 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021855	protein coding gene	Chr17:67152421-67216929 (+)
CAST/EiJ	MGP_CASTEiJ_G0023209	protein coding gene	Chr17:73735662-73809529 (+)
CBA/J	MGP_CBAJ_G0023703	protein coding gene	Chr17:79475275-79548141 (+)
DBA/2J	MGP_DBA2J_G0023832	protein coding gene	Chr17:70055328-70123360 (+)
FVB/NJ	MGP_FVBNJ_G0023798	protein coding gene	Chr17:69521642-69589322 (+)
LP/J	MGP_LPJ_G0023914	protein coding gene	Chr17:74370514-74441991 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023826	protein coding gene	Chr17:79344122-79416172 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024454	protein coding gene	Chr17:72870153-72938213 (+)
PWK/PhJ	MGP_PWKPhJ_G0022955	protein coding gene	Chr17:69358884-69425244 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022766	protein coding gene	Chr17:69587750-69654441 (+)
WSB/EiJ	MGP_WSBEiJ_G0023276	protein coding gene	Chr17:73691155-73760248 (+)

Human Ortholog

LPIN2, lipin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPIN2, lipin 2
Synonyms

CRMO1, MJDS
Links

HGNC:14450

NCBI Gene ID: 9663

neXtProt AC: NX_Q92539

UniProt: Q92539
Chr Location

18p11.31; chr18:2885296-3013144 (-) GRCh38

MGI Vertebrate Homology

Lpin2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPIN2
Gene Tree

Lpin2

Diseases

1 with human LPIN2 associations

				Human Disease	Mouse Models
				chronic recurrent multifocal osteomyelitis IDs chronic recurrent multifocal osteomyelitis DOID:0060645 ICD10CM:M86.3 MESH:C535456 OMIM:259680 ORDO:324964

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice develop ataxia, impaired blance, and tremors with age and show altered cerebellar phospholipid composition and anemia. Mice show diet-induced hepatic triglyceride accumulation.

less

All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

17
cDNA Data

149
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lpin2

less

All Sequences

83
RefSeq

14
UniProt

6
CCDS

CCDS28956.1, CCDS50177.1

Ensembl

ENSMUSG00000024052 (Evidence)
NCBI Gene

64898

			Length	Strain/Species	Flank
genomic	64898	NCBI Gene Model \| MGI Sequence Detail	66287	C57BL/6J	± kb
transcript	NM_001164885	RefSeq \| MGI Sequence Detail	5775	C57BL/6
polypeptide	Q99PI5	UniProt \| EBI \| MGI Sequence Detail	893	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000009895 phosphatidate phosphatase LPIN2

(term hierarchy)
PDB

7KIQ
EC

3.1.3.4
InterPro Domains

IPR036412 HAD-like superfamily

IPR026058 LIPIN family

IPR031703 Lipin, middle domain

IPR013209 Lipin/Ned1/Smp2 (LNS2)

IPR007651 Lipin, N-terminal

IPR031315 LNS2/PITP

less

All nucleic 152

cDNA 151

Primer pair 1

Microarray probesets 6

less

MGI:1915262, MGI:2146881, MGI:2147099

Summaries

All 45

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 12
Earliest

J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lpin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145734	Chr17:71489584-71489591 (+)	-939 bp
Tssr145735	Chr17:71490540-71490565 (+)	26 bp
Tssr145736	Chr17:71490571-71490593 (+)	55 bp
Tssr145737	Chr17:71490596-71490605 (+)	74 bp
Tssr145738	Chr17:71490699-71490710 (+)	178 bp
Tssr145739	Chr17:71505644-71505648 (+)	15,119 bp
Tssr145740	Chr17:71511526-71511549 (+)	21,011 bp
Tssr145741	Chr17:71511568-71511586 (+)	21,050 bp
Tssr145742	Chr17:71511628-71511636 (+)	21,105 bp
Tssr145743	Chr17:71511642-71511688 (+)	21,138 bp
Tssr145744	Chr17:71511693-71511696 (+)	21,168 bp
Tssr145745	Chr17:71521791-71521833 (+)	31,285 bp
Tssr145746	Chr17:71527197-71527206 (+)	36,675 bp
Tssr145747	Chr17:71545492-71545496 (+)	54,967 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24