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Spock2 Gene Detail
Summary
  • Symbol
    Spock2
  • Name
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
  • Synonyms
    Gcap26, mKIAA0275, testican-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891351
    NCBI Gene: 94214
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:59942079-59971020 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.69 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    735 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891351
 protein coding gene Chr10:59942041-59971020 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017265
 protein coding gene Chr10:59321464-59355012 (+)
A/J MGP_AJ_G0017243
 protein coding gene Chr10:57578294-57607167 (+)
AKR/J MGP_AKRJ_G0017203
 protein coding gene Chr10:59081869-59110409 (+)
BALB/cJ MGP_BALBcJ_G0017203
 protein coding gene Chr10:57665490-57694390 (+)
C3H/HeJ MGP_C3HHeJ_G0017026
 protein coding gene Chr10:58990707-59025356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017661
 protein coding gene Chr10:61439892-61471668 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015352
 protein coding gene Chr10:54582632-54610762 (+)
CAST/EiJ MGP_CASTEiJ_G0016597
 protein coding gene Chr10:58929813-58968743 (+)
CBA/J MGP_CBAJ_G0016998
 protein coding gene Chr10:63644927-63686513 (+)
DBA/2J MGP_DBA2J_G0017103
 protein coding gene Chr10:56884426-56914349 (+)
FVB/NJ MGP_FVBNJ_G0017097
 protein coding gene Chr10:56116082-56147336 (+)
LP/J MGP_LPJ_G0017178
 protein coding gene Chr10:59683240-59730555 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017125
 protein coding gene Chr10:66147646-66179371 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017699
 protein coding gene Chr10:58879359-58913742 (+)
PWK/PhJ MGP_PWKPhJ_G0016380
 protein coding gene Chr10:56683250-56713308 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016163
 protein coding gene Chr10:58210714-58248882 (+)
WSB/EiJ MGP_WSBEiJ_G0016661
 protein coding gene Chr10:58792148-58827664 (+)



Homology
more
  • Human Ortholog
    SPOCK2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPOCK2, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
  • Synonyms
    testican-2
  • Links
    NCBI Gene ID: 9806
    neXtProt AC: NX_Q92563
    UniProt: Q92563

  • Chr Location
    10q22.1; chr10:72059034-72089032 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Spock2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    127
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 94214 NCBI Gene Model | MGI Sequence Detail 28942 C57BL/6J ±  kb
transcript NM_052994 RefSeq | MGI Sequence Detail 3931 C57BL/6  
polypeptide Q9ER58 UniProt | EBI | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 129
    cDNA 127
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18679, MGI:101855, MGI:2143457
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:300190 Hadchouel A, et al., Overexpression of Spock2 in mice leads to altered lung alveolar development and worsens lesions induced by hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2020 Jul 1;319(1):L71-L81
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory