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Bhmt2 Gene Detail
Summary
  • Symbol
    Bhmt2
  • Name
    betaine-homocysteine methyltransferase 2
  • Synonyms
    C81077, D13Ucla2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891379
    NCBI Gene: 64918
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:93792605-93810810 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.88 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    648 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891379
 protein coding gene Chr13:93792228-93810810 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020827
 protein coding gene Chr13:95014648-95033870 (-)
A/J MGP_AJ_G0020781
 protein coding gene Chr13:91481677-91499440 (-)
AKR/J MGP_AKRJ_G0020755
 protein coding gene Chr13:94270404-94288305 (-)
BALB/cJ MGP_BALBcJ_G0020778
 protein coding gene Chr13:92120713-92138610 (-)
C3H/HeJ MGP_C3HHeJ_G0020571
 protein coding gene Chr13:93966905-93984768 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021214
 protein coding gene Chr13:97912986-97932292 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018781
 protein coding gene Chr13:87338748-87356633 (-)
CAST/EiJ MGP_CASTEiJ_G0020090
 protein coding gene Chr13:93224701-93242740 (-)
CBA/J MGP_CBAJ_G0020530
 protein coding gene Chr13:101800489-101820749 (-)
DBA/2J MGP_DBA2J_G0020655
 protein coding gene Chr13:91268621-91286516 (-)
FVB/NJ MGP_FVBNJ_G0020636
 protein coding gene Chr13:90060451-90078678 (-)
LP/J MGP_LPJ_G0020730
 protein coding gene Chr13:95144998-95157519 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020664
 protein coding gene Chr13:102306392-102324853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021254
 protein coding gene Chr13:93647371-93665249 (-)
PWK/PhJ MGP_PWKPhJ_G0019842
 protein coding gene Chr13:89982162-89998069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019666
 protein coding gene Chr13:89932528-89953895 (-)
WSB/EiJ MGP_WSBEiJ_G0020147
 protein coding gene Chr13:94152385-94173991 (-)



Homology
more
  • Human Ortholog
    BHMT2, betaine--homocysteine S-methyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BHMT2, betaine--homocysteine S-methyltransferase 2
  • Links
    NCBI Gene ID: 23743
    neXtProt AC: NX_Q9H2M3
    UniProt: Q9H2M3

  • Chr Location
    5q14.1; chr5:79069767-79090069 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BHMT2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    866
  • Tissues
    115
  • cDNA Data
    45
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 64918 NCBI Gene Model | MGI Sequence Detail 18206 C57BL/6J ±  kb
transcript NM_022884 RefSeq | MGI Sequence Detail 2090 ZRU/MplStud  
polypeptide Q91WS4 UniProt | EBI | MGI Sequence Detail 363 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 46
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-3672, MGI:2145520, MGI:89883
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:312368 Imbard A, et al., Liver and brain differential expression of one-carbon metabolism genes during ontogenesis. Sci Rep. 2021 Oct 26;11(1):21132
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory