Onecut2 MGI Mouse Gene Detail - MGI:1891408 - one cut domain, family member 2

Symbol

Onecut2
Name

one cut domain, family member 2
Synonyms

Oc2, OC-2

Feature Type

protein coding gene
IDs

MGI:1891408
NCBI Gene: 225631
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:64473098-64531559 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 37.33 cM, cytoband D3
Mapping Data

1 experiment

SNPs within 2kb

1344 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891408	protein coding gene	Chr18:64473091-64534058 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024502	protein coding gene	Chr18:64384999-64446304 (+)
A/J	MGP_AJ_G0024469	protein coding gene	Chr18:61613642-61671430 (+)
AKR/J	MGP_AKRJ_G0024439	protein coding gene	Chr18:63338319-63397379 (+)
BALB/cJ	MGP_BALBcJ_G0024468	protein coding gene	Chr18:61758006-61817038 (+)
C3H/HeJ	MGP_C3HHeJ_G0024236	protein coding gene	Chr18:63555393-63616305 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024915	protein coding gene	Chr18:66119055-66183984 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022346	protein coding gene	Chr18:61057606-61115399 (+)
CAST/EiJ	MGP_CASTEiJ_G0023709	protein coding gene	Chr18:63468827-63529374 (+)
CBA/J	MGP_CBAJ_G0024206	protein coding gene	Chr18:68258855-68323833 (+)
DBA/2J	MGP_DBA2J_G0024336	protein coding gene	Chr18:61280305-61338898 (+)
FVB/NJ	MGP_FVBNJ_G0024302	protein coding gene	Chr18:60659704-60719057 (+)
LP/J	MGP_LPJ_G0024420	protein coding gene	Chr18:64253851-64317816 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024331	protein coding gene	Chr18:69761199-69825221 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024962	protein coding gene	Chr18:63547627-63609561 (+)
PWK/PhJ	MGP_PWKPhJ_G0023452	protein coding gene	Chr18:61506499-61567099 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023257	protein coding gene	Chr18:63702921-63752282 (+)
WSB/EiJ	MGP_WSBEiJ_G0023773	protein coding gene	Chr18:63403336-63467548 (+)

Human Ortholog

ONECUT2, one cut homeobox 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ONECUT2, one cut homeobox 2
Synonyms

OC-2, OC2
Links

HGNC:8139

NCBI Gene ID: 9480

neXtProt AC: NX_O95948

UniProt: O95948
Chr Location

18q21.31; chr18:57435374-57491298 (+) GRCh38

MGI Vertebrate Homology

Onecut2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ONECUT2
Gene Tree

Onecut2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in abnormal bile duct development.

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All GO Annotations

32
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

997
Tissues

117
cDNA Data

10
Literature Summary

54

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase onecut2

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS29302.2

Ensembl

ENSMUSG00000045991 (Evidence)
NCBI Gene

225631

			Length	Strain/Species	Flank
genomic	225631	NCBI Gene Model \| MGI Sequence Detail	58462	C57BL/6J	± kb
transcript	NM_194268	RefSeq \| MGI Sequence Detail	13728	C57BL/6
polypeptide	Q6XBJ3	UniProt \| EBI \| MGI Sequence Detail	505	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011640 one cut domain family member 2

(term hierarchy)
InterPro Domains

IPR003350 CUT domain

IPR051649 CUT Homeobox Domain-Containing Protein

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR010982 Lambda repressor-like, DNA-binding domain superfamily

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All nucleic 16

cDNA 10

Primer pair 4

Other 2

Microarray probesets 3

Summaries

All 80

Developmental Gene Expression 54

Gene Ontology 9

Phenotypes 22
Earliest

J:75967 Vanhorenbeeck V, et al., OC-3, a Novel Mammalian Member of the ONECUT Class of Transcription Factors. Biochem Biophys Res Commun. 2002 Apr 12;292(4):848-54
Latest

J:357897 Renaux E, et al., Arid3c identifies an uncharacterized subpopulation of V2 interneurons during embryonic spinal cord development. Front Cell Neurosci. 2024;18:1466056

TSS for Onecut2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151537	Chr18:64473091-64473113 (+)	4 bp
Tssr151538	Chr18:64473123-64473138 (+)	33 bp
Tssr151539	Chr18:64473296-64473312 (+)	206 bp
Tssr151540	Chr18:64473640-64473657 (+)	551 bp
Tssr151541	Chr18:64519660-64519676 (+)	46,570 bp
Tssr151542	Chr18:64519719-64519730 (+)	46,627 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24