Lgr4 MGI Mouse Gene Detail - MGI:1891468 - leucine-rich repeat-containing G protein-coupled receptor 4

Symbol

Lgr4
Name

leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms

A330106J01Rik, A930009A08Rik, Gpr48

Feature Type

protein coding gene
IDs

MGI:1891468
NCBI Gene: 107515
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:109747992-109844602 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 56.65 cM
Mapping Data

2 experiments

SNPs within 2kb

2402 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891468	protein coding gene	Chr2:109747919-109844602 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026242	protein coding gene	Chr2:112273623-112378395 (+)
A/J	MGP_AJ_G0026203	protein coding gene	Chr2:107573663-107677154 (+)
AKR/J	MGP_AKRJ_G0026183	protein coding gene	Chr2:110596122-110696027 (+)
BALB/cJ	MGP_BALBcJ_G0026212	protein coding gene	Chr2:107843002-107947927 (+)
C3H/HeJ	MGP_C3HHeJ_G0025962	protein coding gene	Chr2:110889360-110989224 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026664	protein coding gene	Chr2:115934053-116036835 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024049	protein coding gene	Chr2:103128253-103225546 (+)
CAST/EiJ	MGP_CASTEiJ_G0025427	protein coding gene	Chr2:111391450-111492002 (+)
CBA/J	MGP_CBAJ_G0025940	protein coding gene	Chr2:119924451-120033530 (+)
DBA/2J	MGP_DBA2J_G0026078	protein coding gene	Chr2:107073056-107169624 (+)
FVB/NJ	MGP_FVBNJ_G0026041	protein coding gene	Chr2:105999120-106103489 (+)
LP/J	MGP_LPJ_G0026181	protein coding gene	Chr2:112457003-112557052 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026065	protein coding gene	Chr2:124096870-124202691 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026717	protein coding gene	Chr2:110747650-110845008 (+)
PWK/PhJ	MGP_PWKPhJ_G0025162	protein coding gene	Chr2:106711061-106809074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024962	protein coding gene	Chr2:109975201-110078464 (+)
WSB/EiJ	MGP_WSBEiJ_G0025494	protein coding gene	Chr2:111507187-111609898 (+)

Human Ortholog

LGR4, leucine rich repeat containing G protein-coupled receptor 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGR4, leucine rich repeat containing G protein-coupled receptor 4
Synonyms

BNMD17, DPSL, GPR48
Links

HGNC:13299

NCBI Gene ID: 55366

neXtProt AC: NX_Q9BXB1

UniProt: Q9BXB1
Chr Location

11p14.1; chr11:27365961-27472790 (-) GRCh38

MGI Vertebrate Homology

Lgr4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LGR4
Gene Tree

Lgr4

Diseases

1 with Lgr4 mouse models

Human Disease

Mouse Models

glaucoma

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

99 phenotypes from 6 alleles in 9 genetic backgrounds
14 phenotypes from multigenic genotypes
4 images
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

84
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

68
Radiation induced

2
Targeted

9
Genomic Mutations

3 involving Lgr4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for a knock-out allele show embryonic and perinatal death, open eyelids, and abnormal renal development. One gene trap mutation leads to reduced body weight, sterility, and impaired male reproductive tract development. Another gene trap mutation causes ocular anterior segment anomalies.

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All GO Annotations

37
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

925
Tissues

123
cDNA Data

16
Literature Summary

38

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LGR4

Xenbase lgr4

ZFIN lgr4

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All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS38195.1

Ensembl

ENSMUSG00000050199 (Evidence)
NCBI Gene

107515

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050199	Ensembl Gene Model \| MGI Sequence Detail	96611	C57BL/6J	± kb
transcript	ENSMUST00000046548	Ensembl \| MGI Sequence Detail	5060	Not Applicable
polypeptide	ENSMUSP00000047325	Ensembl \| MGI Sequence Detail	951	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001591 leucine-rich repeat-containing G-protein coupled receptor 4

(term hierarchy)
InterPro Domains

IPR002131 Glycoprotein hormone receptor family

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

A2ARI4 5 sites

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All nucleic 34

Genomic 2

cDNA 18

Primer pair 10

Other 4

Microarray probesets 5

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MGI:1925178, MGI:2441840

Summaries

All 118

Developmental Gene Expression 38

Diseases 1

Gene Ontology 14

Phenotypes 74
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:344581 Saponara E, et al., Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease. Am J Pathol. 2023 Feb;193(2):161-181

TSS for Lgr4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19307	Chr2:109747916-109747937 (+)	-65 bp
Tssr19308	Chr2:109747941-109747983 (+)	-30 bp
Tssr19309	Chr2:109747984-109748001 (+)	1 bp
Tssr19310	Chr2:109748024-109748031 (+)	36 bp
Tssr19311	Chr2:109748068-109748081 (+)	83 bp
Tssr19312	Chr2:109759547-109759590 (+)	11,577 bp
Tssr19313	Chr2:109833911-109833916 (+)	85,922 bp
Tssr19314	Chr2:109842066-109842073 (+)	94,078 bp
Tssr19315	Chr2:109843507-109843519 (+)	95,521 bp
Tssr19316	Chr2:109843842-109843845 (+)	95,852 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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