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Mtmr7 Gene Detail
Summary
  • Symbol
    Mtmr7
  • Name
    myotubularin related protein 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891693
    NCBI Gene: 54384
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr8:41004136-41087840 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM, cytoband B1.2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891693
 protein coding gene Chr8:41003184-41088210 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033555
 protein coding gene Chr8:39355428-39441187 (-)
A/J MGP_AJ_G0033535
 protein coding gene Chr8:37855199-37935685 (-)
AKR/J MGP_AKRJ_G0033459
 protein coding gene Chr8:38973137-39052303 (-)
BALB/cJ MGP_BALBcJ_G0033531
 protein coding gene Chr8:37949057-38032633 (-)
C3H/HeJ MGP_C3HHeJ_G0033243
 protein coding gene Chr8:39367521-39451435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034047
 protein coding gene Chr8:40883700-40968606 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030996
 protein coding gene Chr8:34501359-34580795 (-)
CAST/EiJ MGP_CASTEiJ_G0032571
 protein coding gene Chr8:38898193-38980973 (-)
CBA/J MGP_CBAJ_G0033221
 protein coding gene Chr8:42542410-42630972 (-)
DBA/2J MGP_DBA2J_G0033374
 protein coding gene Chr8:37708422-37787562 (-)
FVB/NJ MGP_FVBNJ_G0033319
 protein coding gene Chr8:37285243-37364202 (-)
LP/J MGP_LPJ_G0033464
 protein coding gene Chr8:39376379-39462736 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033361
 protein coding gene Chr8:42327542-42413663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034066
 protein coding gene Chr8:39176943-39259443 (-)
PWK/PhJ MGP_PWKPhJ_G0032280
 protein coding gene Chr8:37254078-37336786 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032112
 protein coding gene Chr8:38378052-38459285 (-)
WSB/EiJ MGP_WSBEiJ_G0032686
 protein coding gene Chr8:39371962-39452731 (-)



Homology
more
  • Human Ortholog
    MTMR7, myotubularin related protein 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTMR7, myotubularin related protein 7
  • Links
    NCBI Gene ID: 9108
    neXtProt AC: NX_Q9Y216
    UniProt: Q9Y216

  • Chr Location
    8p22; chr8:17296794-17413528 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1129
  • Tissues
    168
  • cDNA Data
    11
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039431 Ensembl Gene Model | MGI Sequence Detail 83705 C57BL/6J ±  kb
transcript ENSMUST00000048898 Ensembl | MGI Sequence Detail 2488 Not Applicable  
polypeptide ENSMUSP00000043851 Ensembl | MGI Sequence Detail 660 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 7
References
more
  • Summaries
    All 45
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:62647 Laporte J, et al., Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human. Hum Mol Genet. 1998 Oct;7(11):1703-12
  • Latest
    J:349238 Weidner P, et al., Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction. Cancer Lett. 2024 Mar 9;588:216783
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory