Stk25 MGI Mouse Gene Detail - MGI:1891699 - serine/threonine kinase 25 (yeast)

Symbol

Stk25
Name

serine/threonine kinase 25 (yeast)
Synonyms

1500019J11Rik, SOK-1, Ste20-like, Ysk1

Feature Type

protein coding gene
IDs

MGI:1891699
NCBI Gene: 59041
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:93548473-93581937 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 47.25 cM
Mapping Data

3 experiments

SNPs within 2kb

725 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891699	protein coding gene	Chr1:93547473-93586381 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016345	protein coding gene	Chr1:95256743-95273183 (-)
A/J	MGP_AJ_G0016326	protein coding gene	Chr1:91839732-91883229 (-)
AKR/J	MGP_AKRJ_G0016287	protein coding gene	Chr1:94551848-94568773 (-)
BALB/cJ	MGP_BALBcJ_G0016282	protein coding gene	Chr1:92022885-92062469 (-)
C3H/HeJ	MGP_C3HHeJ_G0016111	protein coding gene	Chr1:94807977-94849779 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016741	protein coding gene	Chr1:98875564-98917547 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014459	protein coding gene	Chr1:86088373-86129286 (-)
CAST/EiJ	MGP_CASTEiJ_G0015694	protein coding gene	Chr1:94139940-94185691 (-)
CBA/J	MGP_CBAJ_G0016085	protein coding gene	Chr1:102077645-102124730 (-)
DBA/2J	MGP_DBA2J_G0016190	protein coding gene	Chr1:91050445-91090738 (-)
FVB/NJ	MGP_FVBNJ_G0016189	protein coding gene	Chr1:90110171-90150059 (-)
LP/J	MGP_LPJ_G0016261	protein coding gene	Chr1:96433253-96450134 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016214	protein coding gene	Chr1:105171767-105216017 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016780	protein coding gene	Chr1:94571330-94615587 (-)
PWK/PhJ	MGP_PWKPhJ_G0015479	protein coding gene	Chr1:90475258-90715458 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015263	protein coding gene	Chr1:93528526-93558772 (-)
WSB/EiJ	MGP_WSBEiJ_G0015754	protein coding gene	Chr1:94393731-94435536 (-)

Human Ortholog

STK25, serine/threonine kinase 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STK25, serine/threonine kinase 25
Synonyms

SOK1, YSK1
Links

HGNC:11404

NCBI Gene ID: 10494

neXtProt AC: NX_O00506

UniProt: O00506
Chr Location

2q37.3; chr2:241492670-241509730 (-) GRCh38

MGI Vertebrate Homology

Stk25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STK25
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Stk25

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Stk25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Germ line null mutants display normal cortical layers and neuronal migration. Acute loss of expression results in impaired neuronal migration.

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All GO Annotations

59
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

121
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase stk25

ZFIN stk25a, stk25b

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All Sequences

53
RefSeq

7
UniProt

5
CCDS

CCDS15192.1

Ensembl

ENSMUSG00000026277 (Evidence)
NCBI Gene

59041

			Length	Strain/Species	Flank
genomic	59041	NCBI Gene Model \| MGI Sequence Detail	33465	C57BL/6J	± kb
transcript	NM_021537	RefSeq \| MGI Sequence Detail	3254	ZRU/MplStud
polypeptide	Q9Z2W1	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000002350 serine/threonine-protein kinase 25

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR048288 Programmed cell death protein 10, dimerisation domain

IPR046409 Programmed cell death protein 10, dimerisation domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR035060 Serine/threonine kinase 25, catalytic domain

IPR050629 STE20/SPS1-related Proline-Alanine-rich Kinase

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 3

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MGI:1203523, MGI:1916237, MGI:2138417, MGI:2138719

Summaries

All 65

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:334566 Yang X, et al., Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation. JCI Insight. 2023 Mar 8;8(5)

TSS for Stk25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13043	Chr1:93581920-93581934 (-)	10 bp
Tssr13042	Chr1:93581866-93581877 (-)	65 bp
Tssr13041	Chr1:93563472-93563483 (-)	18,459 bp
Tssr13040	Chr1:93563414-93563433 (-)	18,513 bp
Tssr13039	Chr1:93563381-93563396 (-)	18,548 bp
Tssr13038	Chr1:93563363-93563374 (-)	18,568 bp
Tssr13037	Chr1:93563343-93563354 (-)	18,588 bp
Tssr13036	Chr1:93562859-93562910 (-)	19,052 bp
Tssr13035	Chr1:93562829-93562839 (-)	19,103 bp
Tssr13034	Chr1:93549718-93549722 (-)	32,217 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24