Gpa33 MGI Mouse Gene Detail - MGI:1891703 - glycoprotein A33 transmembrane

Symbol

Gpa33
Name

glycoprotein A33 transmembrane
Synonyms

2010310L10Rik, 2210401D16Rik, A33 antigen

Feature Type

protein coding gene
IDs

MGI:1891703
NCBI Gene: 59290
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:165957807-165994079 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 73.49 cM
Mapping Data

3 experiments

SNPs within 2kb

1400 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891703	protein coding gene	Chr1:165957790-165994079 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016701	protein coding gene	Chr1:171652187-171694178 (+)
A/J	MGP_AJ_G0016682	protein coding gene	Chr1:164659208-164698118 (+)
AKR/J	MGP_AKRJ_G0016648	protein coding gene	Chr1:169629581-169667308 (+)
BALB/cJ	MGP_BALBcJ_G0016643	protein coding gene	Chr1:165135737-165176040 (+)
C3H/HeJ	MGP_C3HHeJ_G0016467	protein coding gene	Chr1:169852217-169891451 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017104	protein coding gene	Chr1:177401278-177441924 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014813	protein coding gene	Chr1:156530287-156565537 (+)
CAST/EiJ	MGP_CASTEiJ_G0016047	protein coding gene	Chr1:169448729-169487248 (+)
CBA/J	MGP_CBAJ_G0016442	protein coding gene	Chr1:183716928-183760488 (+)
DBA/2J	MGP_DBA2J_G0016548	protein coding gene	Chr1:163525569-163563147 (+)
FVB/NJ	MGP_FVBNJ_G0016546	protein coding gene	Chr1:161961669-161999031 (+)
LP/J	MGP_LPJ_G0016619	protein coding gene	Chr1:172732918-172773865 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016571	protein coding gene	Chr1:191163811-191203791 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017140	protein coding gene	Chr1:169494868-169533348 (+)
PWK/PhJ	MGP_PWKPhJ_G0015833	protein coding gene	Chr1:162731510-162772247 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015620	protein coding gene	Chr1:168337317-168373677 (+)
WSB/EiJ	MGP_WSBEiJ_G0016109	protein coding gene	Chr1:169632609-169671972 (+)

Human Ortholog

GPA33, glycoprotein A33

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPA33, glycoprotein A33
Synonyms

A33
Links

HGNC:4445

NCBI Gene ID: 10223

neXtProt AC: NX_Q99795

UniProt: Q99795
Chr Location

1q24.1; chr1:167052836-167166479 (-) GRCh38

MGI Vertebrate Homology

Gpa33 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPA33
Gene Tree

Gpa33

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Phenotype Summary

20 phenotypes from 2 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

111
Chemically induced (other)

2
Endonuclease-mediated

6
Gene trapped

94
Targeted

9
Genomic Mutations

2 involving Gpa33
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

138 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased susceptibility to induced colitis and impaired oral tolerance to ovalbumin.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

935
Tissues

82
cDNA Data

51
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpa33

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All Sequences

44
RefSeq

6
UniProt

4
CCDS

CCDS15447.1

Ensembl

ENSMUSG00000000544 (Evidence)
NCBI Gene

59290

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000544	Ensembl Gene Model \| MGI Sequence Detail	36273	C57BL/6J	± kb
transcript	ENSMUST00000060833	Ensembl \| MGI Sequence Detail	2515	Not Applicable
polypeptide	ENSMUSP00000060147	Ensembl \| MGI Sequence Detail	319	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008157 cell surface A33 antigen

(term hierarchy)
InterPro Domains

IPR042474 Cell surface A33 antigen

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

Q9JKA5 4 sites

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All nucleic 52

cDNA 52

Microarray probesets 4

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MGI:1921497, MGI:1923785, MGI:2138634

Summaries

All 48

Developmental Gene Expression 4

Gene Ontology 2

Phenotypes 23
Earliest

J:64884 Johnstone CN, et al., Characterization of mouse A33 antigen, a definitive marker for basolateral surfaces of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2000 Sep;279(3):G500-10
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpa33:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9859	Chr1:165957784-165957800 (+)	-15 bp
Tssr9860	Chr1:165957816-165957835 (+)	19 bp
Tssr9861	Chr1:165957980-165957993 (+)	180 bp
Tssr9862	Chr1:165958005-165958031 (+)	211 bp
Tssr9863	Chr1:165958037-165958048 (+)	236 bp
Tssr9864	Chr1:165958086-165958097 (+)	285 bp
Tssr9865	Chr1:165982575-165982586 (+)	24,774 bp
Tssr9866	Chr1:165992985-165992997 (+)	35,184 bp
Tssr9867	Chr1:165993403-165993412 (+)	35,601 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24