Habp4 MGI Mouse Gene Detail - MGI:1891713 - hyaluronic acid binding protein 4

Symbol

Habp4
Name

hyaluronic acid binding protein 4
Synonyms

4933413D03Rik, 4933428J01Rik

Feature Type

protein coding gene
IDs

MGI:1891713
NCBI Gene: 56541
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:64309680-64334351 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 33.26 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

819 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891713	protein coding gene	Chr13:64309638-64334351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020675	protein coding gene	Chr13:64180369-64205870 (+)
A/J	MGP_AJ_G0020629	protein coding gene	Chr13:61852286-61878284 (+)
AKR/J	MGP_AKRJ_G0020606	protein coding gene	Chr13:63902621-63927491 (+)
BALB/cJ	MGP_BALBcJ_G0020627	protein coding gene	Chr13:62268852-62294592 (+)
C3H/HeJ	MGP_C3HHeJ_G0020422	protein coding gene	Chr13:63425076-63450457 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021063	protein coding gene	Chr13:66243028-66269064 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018639	protein coding gene	Chr13:59500996-59525410 (+)
CAST/EiJ	MGP_CASTEiJ_G0019939	protein coding gene	Chr13:63437661-63462314 (+)
CBA/J	MGP_CBAJ_G0020382	protein coding gene	Chr13:68798039-68822505 (+)
DBA/2J	MGP_DBA2J_G0020507	protein coding gene	Chr13:61682700-61707979 (+)
FVB/NJ	MGP_FVBNJ_G0020486	protein coding gene	Chr13:60783633-60808400 (+)
LP/J	MGP_LPJ_G0020581	protein coding gene	Chr13:64453056-64482561 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020515	protein coding gene	Chr13:67742901-67767374 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021105	protein coding gene	Chr13:63213554-63239098 (+)
PWK/PhJ	MGP_PWKPhJ_G0019693	protein coding gene	Chr13:61243610-61285321 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019519	protein coding gene	Chr13:61376437-61419556 (+)
WSB/EiJ	MGP_WSBEiJ_G0019999	protein coding gene	Chr13:63691040-63717229 (+)

Human Ortholog

HABP4, hyaluronan binding protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HABP4, hyaluronan binding protein 4
Synonyms

IHABP-4, IHABP4, Ki-1/57, SERBP1L
Links

HGNC:17062

NCBI Gene ID: 22927

neXtProt AC: NX_Q5JVS0

UniProt: Q5JVS0
Chr Location

9q22.32; chr9:96450102-96491336 (+) GRCh38

MGI Vertebrate Homology

Habp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HABP4
Gene Tree

Habp4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Chemically induced (other)

1
Endonuclease-mediated

1
Genomic Mutations

1 involving Habp4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased proliferation of cells in the bottom of the colon crypts and show increased colon tumor development following chemical induction.

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All GO Annotations

50
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

33
cDNA Data

51
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase habp4

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All Sequences

46
RefSeq

2
UniProt

5
CCDS

CCDS36702.1

Ensembl

ENSMUSG00000021476 (Evidence)
NCBI Gene

56541

			Length	Strain/Species	Flank
genomic	56541	NCBI Gene Model \| MGI Sequence Detail	24672	C57BL/6J	± kb
transcript	NM_019986	RefSeq \| MGI Sequence Detail	2584	ZRU/MplStud
polypeptide	Q9JKS5	UniProt \| EBI \| MGI Sequence Detail	411	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008429 intracellular hyaluronan-binding protein 4

(term hierarchy)
InterPro Domains

IPR006861 Hyaluronan/mRNA-binding protein

IPR032381 Intracellular hyaluronan-binding protein 4, N-terminal domain

IPR039764 RNA binding protein HABP4/SERBP1-like

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All nucleic 52

cDNA 51

Primer pair 1

Microarray probesets 5

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MGI:1918402, MGI:1918461

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 4
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:310581 Melo-Hanchuk TD, et al., Intracellular hyaluronic acid-binding protein 4 (HABP4): a candidate tumor suppressor in colorectal cancer. Oncotarget. 2020 Nov 17;11(46):4325-4337

TSS for Habp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4108	Chr13:64309279-64309284 (+)	-398 bp
Tssr120197	Chr13:64309610-64309646 (+)	-52 bp
Tssr120198	Chr13:64309648-64309673 (+)	-19 bp
Tssr120199	Chr13:64309676-64309724 (+)	20 bp
Tssr120200	Chr13:64309756-64309763 (+)	80 bp
Tssr120201	Chr13:64331675-64331684 (+)	22,000 bp
Tssr120202	Chr13:64331700-64331713 (+)	22,027 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24