Miox MGI Mouse Gene Detail - MGI:1891725

Symbol

Miox
Name

myo-inositol oxygenase
Synonyms

0610009I10Rik, Aldrl6, C85427, RSOR

Feature Type

protein coding gene
IDs

MGI:1891725
NCBI Gene: 56727
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:89218676-89221210 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.82 cM
Mapping Data

2 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891725	protein coding gene	Chr15:89218601-89221218 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022226	protein coding gene	Chr15:90522852-90525469 (+)
A/J	MGP_AJ_G0022185	protein coding gene	Chr15:87060266-87062883 (+)
AKR/J	MGP_AKRJ_G0022160	protein coding gene	Chr15:89635367-89637984 (+)
BALB/cJ	MGP_BALBcJ_G0022191	protein coding gene	Chr15:87165552-87168169 (+)
C3H/HeJ	MGP_C3HHeJ_G0021961	protein coding gene	Chr15:89631773-89634390 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022636	protein coding gene	Chr15:93810784-93813401 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020161	protein coding gene	Chr15:83283453-83286051 (+)
CAST/EiJ	MGP_CASTEiJ_G0021483	protein coding gene	Chr15:90408014-90410631 (+)
CBA/J	MGP_CBAJ_G0021928	protein coding gene	Chr15:96994805-96997422 (+)
DBA/2J	MGP_DBA2J_G0022055	protein coding gene	Chr15:86511125-86513742 (+)
FVB/NJ	MGP_FVBNJ_G0022034	protein coding gene	Chr15:85577639-85580256 (+)
LP/J	MGP_LPJ_G0022126	protein coding gene	Chr15:90681122-90683739 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022054	protein coding gene	Chr15:101394588-101397205 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022651	protein coding gene	Chr15:89675086-89677703 (+)
PWK/PhJ	MGP_PWKPhJ_G0021224	protein coding gene	Chr15:86573133-86575750 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021058	protein coding gene	Chr15:89419404-89421983 (+)
WSB/EiJ	MGP_WSBEiJ_G0021532	protein coding gene	Chr15:90162334-90164951 (+)

Human Ortholog

MIOX, myo-inositol oxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIOX, myo-inositol oxygenase
Synonyms

ALDRL6
Links

HGNC:14522

NCBI Gene ID: 55586

neXtProt AC: NX_Q9UGB7

UniProt: Q9UGB7
Chr Location

22q13.33; chr22:50486784-50490648 (+) GRCh38

MGI Vertebrate Homology

Miox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MIOX
Gene Tree

Miox

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Miox
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

859
Tissues

106
cDNA Data

205
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase miox

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All Sequences

44
RefSeq

2
UniProt

2
CCDS

CCDS27745.1

Ensembl

ENSMUSG00000022613 (Evidence)
NCBI Gene

56727

			Length	Strain/Species	Flank
genomic	56727	NCBI Gene Model \| MGI Sequence Detail	2535	C57BL/6J	± kb
transcript	NM_019977	RefSeq \| MGI Sequence Detail	1074	FVB/N
polypeptide	Q9QXN5	UniProt \| EBI \| MGI Sequence Detail	285	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010417 inositol oxygenase

(term hierarchy)
PDB

2HUO, 3BXD
EC

1.13.99.1
InterPro Domains

IPR018170 Aldo/keto reductase, conserved site

IPR007828 Inositol oxygenase
GlyGen

Q9QXN5 1 site, 1 O-linked glycan (1 site)

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All nucleic 205

cDNA 205

Microarray probesets 3

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MGI:1915595, MGI:2145970, MGI:2146309

Summaries

All 66

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:344123 Zheng X, et al., Myo-inositol oxygenase overexpression exacerbates cadmium-induced kidney injury via oxidant stress and necroptosis. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F344-F359

TSS for Miox:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132656	Chr15:89218656-89218675 (+)	-10 bp
Tssr132657	Chr15:89219173-89219182 (+)	502 bp
Tssr132658	Chr15:89219189-89219220 (+)	529 bp
Tssr132659	Chr15:89220219-89220228 (+)	1,548 bp
Tssr4688	Chr15:89221056-89221065 (+)	2,385 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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