Patz1 MGI Mouse Gene Detail - MGI:1891832 - POZ (BTB) and AT hook containing zinc finger 1

Symbol

Patz1
Name

POZ (BTB) and AT hook containing zinc finger 1
Synonyms

8430401L15Rik, MAZR, POZ-AT hook-zinc finger protein, Zfp278

Feature Type

protein coding gene
IDs

MGI:1891832
NCBI Gene: 56218
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr11:3239131-3259083 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 2.30 cM
Mapping Data

2 experiments

SNPs within 2kb

376 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891832	protein coding gene	Chr11:3238874-3259083 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017954	protein coding gene	Chr11:138406-158487 (+)
A/J	MGP_AJ_G0017927	protein coding gene	Chr11:202099-222101 (+)
AKR/J	MGP_AKRJ_G0017891	protein coding gene	Chr11:205560-227699 (+)
BALB/cJ	MGP_BALBcJ_G0017895	protein coding gene	Chr11:173764-194816 (+)
C3H/HeJ	MGP_C3HHeJ_G0017708	protein coding gene	Chr11:146951-170771 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018348	protein coding gene	Chr11:200136-224512 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016007	protein coding gene	Chr11:117966-138689 (+)
CAST/EiJ	MGP_CASTEiJ_G0017270	protein coding gene	Chr11:94816-118383 (+)
CBA/J	MGP_CBAJ_G0017683	protein coding gene	Chr11:370239-395169 (+)
DBA/2J	MGP_DBA2J_G0017794	protein coding gene	Chr11:123596-144345 (+)
FVB/NJ	MGP_FVBNJ_G0017785	protein coding gene	Chr11:149316-169643 (+)
LP/J	MGP_LPJ_G0017864	protein coding gene	Chr11:244606-264933 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017811	protein coding gene	Chr11:127649-148315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018387	protein coding gene	Chr11:213520-233715 (+)
PWK/PhJ	MGP_PWKPhJ_G0017050	protein coding gene	Chr11:97153-117771 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016846	protein coding gene	Chr11:170078-191106 (+)
WSB/EiJ	MGP_WSBEiJ_G0017324	protein coding gene	Chr11:92640-114473 (+)

Human Ortholog

PATZ1, POZ/BTB and AT hook containing zinc finger 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PATZ1, POZ/BTB and AT hook containing zinc finger 1
Synonyms

dJ400N23, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG
Links

HGNC:13071

NCBI Gene ID: 23598

neXtProt AC: NX_Q9HBE1

UniProt: Q9HBE1
Chr Location

22q12.2; chr22:31325804-31346346 (-) GRCh38

MGI Vertebrate Homology

Patz1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PATZ1
Gene Tree

Patz1

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Phenotype Summary

43 phenotypes from 4 alleles in 6 genetic backgrounds
4 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

56
Endonuclease-mediated

1
Gene trapped

47
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit some embryonic and fetal lethality, exencephaly, nervous system defects, outflow defects, transposition of great arteries, postnatal growth retardation and male and female infertility.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1231
Tissues

282
cDNA Data

15
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase patz1

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All Sequences

81
RefSeq

8
UniProt

9
CCDS

CCDS24356.1, CCDS56754.1

Ensembl

ENSMUSG00000020453 (Evidence)
NCBI Gene

56218

			Length	Strain/Species	Flank
genomic	56218	NCBI Gene Model \| MGI Sequence Detail	19953	C57BL/6J	± kb
transcript	NM_001253691	RefSeq \| MGI Sequence Detail	3210	C57BL/6
polypeptide	Q5NBY9	UniProt \| EBI \| MGI Sequence Detail	687	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000012312 POZ-, AT hook-, and zinc finger-containing protein 1

(term hierarchy)
PDB

6GUV
InterPro Domains

IPR000210 BTB/POZ domain

IPR000637 HMG-I/HMG-Y, DNA-binding, conserved site

IPR011333 SKP1/BTB/POZ domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 18

cDNA 15

Primer pair 3

Microarray probesets 3

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MGI:1921776, MGI:2144162

Summaries

All 67

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 24
Earliest

J:64686 Kobayashi A, et al., A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain. Mol Cell Biol. 2000 Mar;20(5):1733-46
Latest

J:357756 Patel S, et al., Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors. Nat Commun. 2024 Oct 2;15(1):8533

TSS for Patz1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100021	Chr11:3239168-3239194 (+)	50 bp
Tssr100022	Chr11:3239680-3239741 (+)	580 bp
Tssr100023	Chr11:3239880-3239922 (+)	770 bp
Tssr100024	Chr11:3240300-3240348 (+)	1,193 bp
Tssr100025	Chr11:3240463-3240485 (+)	1,343 bp
Tssr100026	Chr11:3240808-3240839 (+)	1,693 bp
Tssr100027	Chr11:3241327-3241371 (+)	2,218 bp
Tssr100028	Chr11:3241738-3241766 (+)	2,621 bp
Tssr100029	Chr11:3241829-3241848 (+)	2,708 bp
Tssr100030	Chr11:3242286-3242340 (+)	3,182 bp
Tssr100031	Chr11:3242443-3242452 (+)	3,317 bp
Tssr100032	Chr11:3242938-3242962 (+)	3,819 bp
Tssr100033	Chr11:3243109-3243128 (+)	3,988 bp
Tssr100034	Chr11:3243138-3243160 (+)	4,018 bp
Tssr100035	Chr11:3243228-3243245 (+)	4,106 bp
Tssr100036	Chr11:3243276-3243288 (+)	4,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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