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Cpb2 Gene Detail
Summary
  • Symbol
    Cpb2
  • Name
    carboxypeptidase B2
  • Synonyms
    1110032P04Rik, 4930405E17Rik, carboxypeptidase R, carboxypeptidase U, CPR, CPU, TAFI, thrombin-activatable fibrinolysis inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891837
    NCBI Gene: 56373
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75479727-75520995 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.73 cM, cytoband D2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891837
 protein coding gene Chr14:75479727-75520995 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021568
 protein coding gene Chr14:70058712-70104670 (+)
A/J MGP_AJ_G0021526
 protein coding gene Chr14:68495610-68539760 (+)
AKR/J MGP_AKRJ_G0021503
 protein coding gene Chr14:70527444-70576449 (+)
BALB/cJ MGP_BALBcJ_G0021533
 protein coding gene Chr14:68296200-68341964 (+)
C3H/HeJ MGP_C3HHeJ_G0021310
 protein coding gene Chr14:70260357-70304805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021973
 protein coding gene Chr14:73128975-73176194 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019511
 protein coding gene Chr14:66138553-66179222 (+)
CAST/EiJ MGP_CASTEiJ_G0020827
 protein coding gene Chr14:66926025-66970401 (+)
CBA/J MGP_CBAJ_G0021278
 protein coding gene Chr14:75466010-75510579 (+)
DBA/2J MGP_DBA2J_G0021401
 protein coding gene Chr14:67902718-67945122 (+)
FVB/NJ MGP_FVBNJ_G0021379
 protein coding gene Chr14:67231550-67276479 (+)
LP/J MGP_LPJ_G0021471
 protein coding gene Chr14:71220568-71265823 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021406
 protein coding gene Chr14:74256994-74304691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021996
 protein coding gene Chr14:69819319-69864135 (+)
PWK/PhJ MGP_PWKPhJ_G0020570
 protein coding gene Chr14:64639107-64681859 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020406
 protein coding gene Chr14:65772078-65819687 (+)
WSB/EiJ MGP_WSBEiJ_G0020880
 protein coding gene Chr14:70149806-70194325 (+)



Homology
more
  • Human Ortholog
    CPB2, carboxypeptidase B2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPB2, carboxypeptidase B2
  • Synonyms
    CPU, PCPB, TAFI
  • Links
    NCBI Gene ID: 1361
    neXtProt AC: NX_Q96IY4
    UniProt: Q96IY4

  • Chr Location
    13q14.13; chr13:46053186-46105033 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CPB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit altered plasma clot lysis and may show reduced bleomycin-induced lung fibrosis, impaired healing of cutaneous wounds and colonic anastomoses, altered glomerular structure, or complement-mediated lethal inflammation after LPS sensitization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    222
  • cDNA Data
    46
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56373 NCBI Gene Model | MGI Sequence Detail 41269 C57BL/6J ±  kb
    transcript NM_019775 RefSeq | MGI Sequence Detail 1503 C57BL/6  
    polypeptide Q9JHH6 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 47
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915976, MGI:1923026, MGI:2145607
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:65056 Marx PF, et al., Characterization of mouse thrombin-activatable fibrinolysis inhibitor. Thromb Haemost. 2000 Feb;83(2):297-303
    • Latest
      J:320933 Basu S, et al., Role of thrombomodulin expression on hematopoietic stem cells. J Thromb Haemost. 2020 Jan;18(1):123-135
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory