Ity3 QTL Detail

Summary

• Symbol
  Ity3
• Name
  immunity to S. typhimurium 3

• Feature Type
  QTL
• IDs
  MGI:1891848
  NCBI Gene: 112208
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr1:131156308-165139464 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 56.92 cM (cM position of peak correlated region/marker)
• Mapping Data
  4 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 2 alleles in 2 genetic backgrounds
  3 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112208

References

• Summaries
  All 7

  Phenotypes 3
• Earliest
  J:45962 Sebastiani G, et al., Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics. 1998 Jan 15;47(2):180-6
• Latest
  J:244656 Khan RT, et al., Genetic dissection of the ity3 locus identifies a role for ncf2 co-expression modules and suggests selp as a candidate gene underlying the ity3.2 locus. Front Immunol. 2014;5:375

Candidate Genes for Ity3:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Tlr5	Chr1:182782353-182804010 (+)	J:108692	Congenic animals derived from resistant C57BL/6J and susceptible MOLF/Ei parentals were used to test the candidacy of Tlr5 for the Salmonella susceptibility QTL Ity3 (71.5 cM on chromosome 1). Introgression of MOLF/Ei-derived Ity3 onto a C57BL/6J geneticbackround included the Tlr5 locus. The following parentals and congeic lines were tested by injection with flagellin: C57BL/6J MOLF/Ei B6.MOLF-Slc11a1 Ity3 (homozygous for MOLF/Ei alleles at Tlr5) B6.MOLF-Slc11a1 Ity3 (heterozygous for C57BL/6J and MOLF/Ei alleles at Tlr5) B6.MOLF-Slc11a1 (homozygous for C57BL/6J alleles at Tlr5) Serum IL-6 and CXCL-1 were measured at different time points (0, 60, and 90 minutes) after flagellin administration. Congenic animals homozygous for MOLF/Ei alleles at Tlr5 (B6.MOLF-Slc11a1 Ity3)exhibited the strongest response to flagellen stimulation out of all lines tested as indicated by significantly higher levels of serum IL-6 and CXCL-1. Parental strain MOLF/Ei exhibits the lowest serum IL-6 and CXCL-1 levels compared to parental C57BL/6Jand all 3 congenic lines. The results indicate the effect of Tlr5 is dependent on strain background. Therefore, it is unlikely Tlr5 is responsible for the Ity3 susceptible phenotype.