Foxo4 MGI Mouse Gene Detail - MGI:1891915

Symbol

Foxo4
Name

forkhead box O4
Synonyms

afx, Afxh, Foxo4, Mllt7

Feature Type

protein coding gene
IDs

MGI:1891915
NCBI Gene: 54601
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:100298134-100304479 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 43.89 cM
Mapping Data

2 experiments

SNPs within 2kb

93 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891915	protein coding gene	ChrX:100297855-100304479 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035953	protein coding gene	ChrX:97753017-97760174 (+)
A/J	MGP_AJ_G0035938	protein coding gene	ChrX:97759693-97766038 (+)
AKR/J	MGP_AKRJ_G0035854	protein coding gene	ChrX:100557812-100564159 (+)
BALB/cJ	MGP_BALBcJ_G0035921	protein coding gene	ChrX:96498351-96504679 (+)
C3H/HeJ	MGP_C3HHeJ_G0035630	protein coding gene	ChrX:98160346-98166911 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036450	protein coding gene	ChrX:100661116-100667433 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033280	protein coding gene	ChrX:95514019-95520376 (+)
CAST/EiJ	MGP_CASTEiJ_G0034917	protein coding gene	ChrX:82464644-82470972 (+)
CBA/J	MGP_CBAJ_G0035605	protein coding gene	ChrX:103774759-103782790 (+)
DBA/2J	MGP_DBA2J_G0035759	protein coding gene	ChrX:96973561-96979885 (+)
FVB/NJ	MGP_FVBNJ_G0035697	protein coding gene	ChrX:96356857-96363530 (+)
LP/J	MGP_LPJ_G0035849	protein coding gene	ChrX:98715130-98721475 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035732	protein coding gene	ChrX:108326565-108332931 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036477	protein coding gene	ChrX:97446424-97452768 (+)
PWK/PhJ	MGP_PWKPhJ_G0034616	protein coding gene	ChrX:80071830-80078200 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034444	protein coding gene	ChrX:83370517-83376839 (+)
WSB/EiJ	MGP_WSBEiJ_G0035056	protein coding gene	ChrX:96150781-96158249 (+)

Human Ortholog

FOXO4, forkhead box O4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXO4, forkhead box O4
Synonyms

AFX, AFX1, MLLT7
Links

HGNC:7139

NCBI Gene ID: 4303

neXtProt AC: NX_P98177

UniProt: P98177
Chr Location

Xq13.1; chrX:71095851-71103532 (+) GRCh38

MGI Vertebrate Homology

Foxo4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXO4
Gene Tree

Foxo4

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
20 phenotypes from multigenic genotypes
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

4
Gene trapped

2
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice hemizygous and homozygous for a knock-out allele are viable, fertile and grossly normal with no detectable histological abnormalities in most tissues.

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All GO Annotations

63
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

106
cDNA Data

38
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXO4

Xenbase foxo4

ZFIN foxo4

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All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS41077.1

Ensembl

ENSMUSG00000042903 (Evidence)
NCBI Gene

54601

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042903	Ensembl Gene Model \| MGI Sequence Detail	6346	C57BL/6J	± kb
transcript	ENSMUST00000062000	Ensembl \| MGI Sequence Detail	3162	Not Applicable
polypeptide	ENSMUSP00000059420	Ensembl \| MGI Sequence Detail	505	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007642 forkhead box protein O4

(term hierarchy)
InterPro Domains

IPR047409 Forkhead box protein O4, forkhead domain

IPR001766 Fork head domain

IPR030456 Fork head domain conserved site 2

IPR032067 FOXO protein, transactivation domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 43

cDNA 38

Primer pair 3

Other 2

Microarray probesets 4

Summaries

All 141

Developmental Gene Expression 25

Diseases 1

Gene Ontology 10

Phenotypes 78
Earliest

J:63676 Furuyama T, et al., Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem J. 2000 Jul 15;349(Pt 2):629-34
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Foxo4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161636	ChrX:100297759-100297777 (+)	-366 bp
Tssr161637	ChrX:100298072-100298101 (+)	-47 bp
Tssr161638	ChrX:100298165-100298180 (+)	39 bp
Tssr161639	ChrX:100303778-100303785 (+)	5,648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24