Hnrnph1 MGI Mouse Gene Detail - MGI:1891925 - heterogeneous nuclear ribonucleoprotein H1

Symbol

Hnrnph1
Name

heterogeneous nuclear ribonucleoprotein H1
Synonyms

E430005G16Rik, Hnrph1

Feature Type

protein coding gene
IDs

MGI:1891925
NCBI Gene: 59013
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:50267817-50277355 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.56 cM, cytoband B1.2
Mapping Data

3 experiments

SNPs within 2kb

164 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891925	protein coding gene	Chr11:50266084-50277355 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018249	protein coding gene	Chr11:49557330-49566868 (+)
A/J	MGP_AJ_G0018217	protein coding gene	Chr11:47659201-47668846 (+)
AKR/J	MGP_AKRJ_G0018187	protein coding gene	Chr11:49171348-49181052 (+)
BALB/cJ	MGP_BALBcJ_G0018187	protein coding gene	Chr11:47930172-47939495 (+)
C3H/HeJ	MGP_C3HHeJ_G0018000	protein coding gene	Chr11:49170222-49180017 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018638	protein coding gene	Chr11:51022181-51032735 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016291	protein coding gene	Chr11:45273692-45283342 (+)
CAST/EiJ	MGP_CASTEiJ_G0017562	protein coding gene	Chr11:49150798-49161892 (+)
CBA/J	MGP_CBAJ_G0017975	protein coding gene	Chr11:53385888-53395426 (+)
DBA/2J	MGP_DBA2J_G0018082	protein coding gene	Chr11:47448079-47457619 (+)
FVB/NJ	MGP_FVBNJ_G0018076	protein coding gene	Chr11:47080462-47091450 (+)
LP/J	MGP_LPJ_G0018157	protein coding gene	Chr11:49896536-49906172 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018101	protein coding gene	Chr11:54902818-54915268 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018682	protein coding gene	Chr11:49274427-49283964 (+)
PWK/PhJ	MGP_PWKPhJ_G0017340	protein coding gene	Chr11:47853134-47863062 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017135	protein coding gene	Chr11:48972998-48996522 (+)
WSB/EiJ	MGP_WSBEiJ_G0017615	protein coding gene	Chr11:48910847-48923109 (+)

Human Ortholog

HNRNPH1, heterogeneous nuclear ribonucleoprotein H1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPH1, heterogeneous nuclear ribonucleoprotein H1
Synonyms

hnRNPH, HNRPH, HNRPH1, NEDCDS
Links

HGNC:5041

NCBI Gene ID: 3187

neXtProt AC: NX_P31943

UniProt: P31943
Chr Location

5q35.3; chr5:179614178-179634784 (-) GRCh38

MGI Vertebrate Homology

Hnrnph1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HNRNPH1
Gene Tree

Hnrnph1

Diseases

1 with human HNRNPH1 associations

				Human Disease	Mouse Models
				Sjogren's syndrome IDs Sjogren's syndrome DOID:12894 DOID:416 ICD10CM:M35.0 ICD9CM:710.2 MESH:D012859 NCI:C26883 NCI:C70647 OMIM:270150 UMLS_CUI:C0086981 UMLS_CUI:C1527336

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

24
Targeted

6
Genomic Mutations

1 involving Hnrnph1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a knock-out allele show reduced methamphetamine-induced locomotor activity.

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All GO Annotations

24
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

745
Tissues

39
cDNA Data

16
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnrnph1

ZFIN hnrnph1

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All Sequences

146
RefSeq

76
UniProt

4
CCDS

CCDS24634.1, CCDS83800.1

Ensembl

ENSMUSG00000007850 (Evidence)
NCBI Gene

59013

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007850	Ensembl Gene Model \| MGI Sequence Detail	9539	C57BL/6J	± kb
transcript	ENSMUST00000077817	Ensembl \| MGI Sequence Detail	2126	Not Applicable
polypeptide	ENSMUSP00000076989	Ensembl \| MGI Sequence Detail	472	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008666 heterogeneous nuclear ribonucleoprotein H

(term hierarchy)
InterPro Domains

IPR050666 Epithelial Splicing Regulatory

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR012996 Zinc finger, CHHC-type
GlyGen

O35737 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 1

Other 1

Microarray probesets 5

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MGI:2144245, MGI:2444105

Summaries

All 60

Developmental Gene Expression 10

Gene Ontology 8

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hnrnph1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101247	Chr11:50267738-50267751 (+)	-72 bp
Tssr101248	Chr11:50267809-50267831 (+)	3 bp
Tssr101249	Chr11:50267840-50267851 (+)	29 bp
Tssr101250	Chr11:50267874-50267890 (+)	65 bp
Tssr101251	Chr11:50267896-50267913 (+)	88 bp
Tssr101252	Chr11:50268584-50268606 (+)	778 bp
Tssr101253	Chr11:50268837-50268873 (+)	1,038 bp
Tssr101254	Chr11:50269199-50269215 (+)	1,390 bp
Tssr101255	Chr11:50272331-50272379 (+)	4,538 bp
Tssr101256	Chr11:50273620-50273643 (+)	5,815 bp
Tssr101257	Chr11:50273843-50273855 (+)	6,032 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24