Hs1bp3 MGI Mouse Gene Detail - MGI:1913224

Symbol

Hs1bp3
Name

HCLS1 binding protein 3

Feature Type

protein coding gene
IDs

MGI:1913224
NCBI Gene: 58240
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:8363432-8393824 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 3.85 cM
Mapping Data

2 experiments

SNPs within 2kb

1056 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913224	protein coding gene	Chr12:8363389-8393824 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019584	protein coding gene	Chr12:5350273-5382326 (+)
A/J	MGP_AJ_G0019551	protein coding gene	Chr12:5210232-5240612 (+)
AKR/J	MGP_AKRJ_G0019521	protein coding gene	Chr12:5550080-5582517 (+)
BALB/cJ	MGP_BALBcJ_G0019526	protein coding gene	Chr12:5288616-5318981 (+)
C3H/HeJ	MGP_C3HHeJ_G0019332	protein coding gene	Chr12:5333998-5365087 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019975	protein coding gene	Chr12:5492058-5522467 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017600	protein coding gene	Chr12:5013353-5045255 (+)
CAST/EiJ	MGP_CASTEiJ_G0018887	protein coding gene	Chr12:5373091-5417199 (+)
CBA/J	MGP_CBAJ_G0019303	protein coding gene	Chr12:6029492-6062223 (+)
DBA/2J	MGP_DBA2J_G0019416	protein coding gene	Chr12:5164086-5194910 (+)
FVB/NJ	MGP_FVBNJ_G0019407	protein coding gene	Chr12:5129690-5160030 (+)
LP/J	MGP_LPJ_G0019487	protein coding gene	Chr12:5393029-5423349 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019440	protein coding gene	Chr12:5841113-5873248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020014	protein coding gene	Chr12:5315562-5346420 (+)
PWK/PhJ	MGP_PWKPhJ_G0018653	protein coding gene	Chr12:5210890-5241723 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018444	protein coding gene	Chr12:5317206-5347441 (+)
WSB/EiJ	MGP_WSBEiJ_G0018938	protein coding gene	Chr12:5348406-5379800 (+)

Human Ortholog

HS1BP3, HCLS1 binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HS1BP3, HCLS1 binding protein 3
Synonyms

ETM2, HS1-BP3
Links

HGNC:24979

NCBI Gene ID: 64342

neXtProt AC: NX_Q53T59

UniProt: Q53T59
Chr Location

2p24.1; chr2:20553861-20651130 (-) GRCh38

MGI Vertebrate Homology

Hs1bp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HS1BP3
Gene Tree

Hs1bp3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

4
Gene trapped

2
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

22 strains or lines available

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

47

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hs1bp3

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All Sequences

66
RefSeq

8
UniProt

4
CCDS

CCDS49024.1

Ensembl

ENSMUSG00000020605 (Evidence)
NCBI Gene

58240

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020605	Ensembl Gene Model \| MGI Sequence Detail	30393	C57BL/6J	± kb
transcript	ENSMUST00000020927	Ensembl \| MGI Sequence Detail	2959	Not Applicable
polypeptide	ENSMUSP00000020927	Ensembl \| MGI Sequence Detail	395	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008756 HCLS1-binding protein 3

(term hierarchy)
InterPro Domains

IPR039701 HCLS1-binding protein 3

IPR037901 HCLS1-binding protein 3, PX domain

IPR001683 Phox homology

IPR036871 PX domain superfamily

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All nucleic 47

cDNA 47

Microarray probesets 4

Summaries

All 29

Gene Ontology 4

Phenotypes 8
Earliest

J:64960 Takemoto Y, et al., Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. Int Immunol. 1999 Dec;11(12):1957-64
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Hs1bp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112714	Chr12:8363425-8363454 (+)	8 bp
Tssr112715	Chr12:8363455-8363462 (+)	27 bp
Tssr112716	Chr12:8382201-8382214 (+)	18,776 bp
Tssr112717	Chr12:8382218-8382228 (+)	18,791 bp
Tssr112718	Chr12:8392932-8392955 (+)	29,512 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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