Crbn MGI Mouse Gene Detail - MGI:1913277

Symbol

Crbn
Name

cereblon
Synonyms

2610203G15Rik, 2900045O07Rik

Feature Type

protein coding gene
IDs

MGI:1913277
NCBI Gene: 58799
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:106757162-106777038 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 49.24 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

681 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913277	protein coding gene	Chr6:106755205-106777060 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031096	protein coding gene	Chr6:109016462-109036263 (-)
A/J	MGP_AJ_G0031065	protein coding gene	Chr6:104843664-104864014 (-)
AKR/J	MGP_AKRJ_G0030996	protein coding gene	Chr6:107681864-107704070 (-)
BALB/cJ	MGP_BALBcJ_G0031076	protein coding gene	Chr6:104799234-104819298 (-)
C3H/HeJ	MGP_C3HHeJ_G0030632	protein coding gene	Chr6:76636129-76656005 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031535	protein coding gene	Chr6:111854906-111874782 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028699	protein coding gene	Chr6:102307008-102327191 (-)
CAST/EiJ	MGP_CASTEiJ_G0030183	protein coding gene	Chr6:108089954-108109864 (-)
CBA/J	MGP_CBAJ_G0030762	protein coding gene	Chr6:116187695-116207987 (-)
DBA/2J	MGP_DBA2J_G0030915	protein coding gene	Chr6:103979346-103999222 (-)
FVB/NJ	MGP_FVBNJ_G0030869	protein coding gene	Chr6:103076941-103096922 (-)
LP/J	MGP_LPJ_G0030995	protein coding gene	Chr6:109104770-109124571 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030903	protein coding gene	Chr6:120449727-120471188 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031562	protein coding gene	Chr6:107667081-107686957 (-)
PWK/PhJ	MGP_PWKPhJ_G0029899	protein coding gene	Chr6:102980494-103000293 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029727	protein coding gene	Chr6:106496644-106516472 (-)
WSB/EiJ	MGP_WSBEiJ_G0030267	protein coding gene	Chr6:108193681-108213718 (-)

Human Ortholog

CRBN, cereblon

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRBN, cereblon
Synonyms

MRT2, MRT2A
Links

HGNC:30185

NCBI Gene ID: 51185

neXtProt AC: NX_Q96SW2

UniProt: Q96SW2
Chr Location

3p26.2; chr3:3144628-3179727 (-) GRCh38

MGI Vertebrate Homology

Crbn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRBN
Gene Tree

Crbn

Diseases

1 with Crbn mouse models; 1 with human CRBN associations

Human Disease

Mouse Models

autosomal recessive intellectual developmental disorder

IDs

View 2 models

autosomal recessive intellectual developmental disorder 2

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

36 phenotypes from 5 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

5
Spontaneous

1
Targeted

11
Genomic Mutations

1 involving Crbn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

46
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crbn

ZFIN crbn

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All Sequences

58
RefSeq

5
UniProt

2
CCDS

CCDS39583.1, CCDS39584.1

Ensembl

ENSMUSG00000005362 (Evidence)
NCBI Gene

58799

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005362	Ensembl Gene Model \| MGI Sequence Detail	19877	C57BL/6J	± kb
transcript	ENSMUST00000113239	Ensembl \| MGI Sequence Detail	2084	Not Applicable
polypeptide	ENSMUSP00000108865	Ensembl \| MGI Sequence Detail	445	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005851 protein cereblon

(term hierarchy)
PDB

3WX1, 3WX2, 4TZC, 4TZU, 5YIZ, 5YJ0, 5YJ1
InterPro Domains

IPR034750 CULT domain

IPR003111 Lon protease, N-terminal domain

IPR046336 Lon protease, N-terminal domain superfamily

IPR015947 PUA-like superfamily

IPR004910 Yippee/Mis18/Cereblon
GlyGen

Q8C7D2 1 site, 1 N-linked glycan (1 site)

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 7

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MGI:1914412, MGI:1920153, MGI:2141645

Summaries

All 78

Developmental Gene Expression 3

Diseases 2

Gene Ontology 9

Phenotypes 43
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352337 Costas-Insua C, et al., The CB(1) receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls. EMBO Mol Med. 2024 Apr;16(4):755-783

TSS for Crbn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62379	Chr6:106777012-106777056 (-)	4 bp
Tssr62378	Chr6:106771578-106771597 (-)	5,450 bp
Tssr62377	Chr6:106771553-106771577 (-)	5,473 bp
Tssr62376	Chr6:106771172-106771207 (-)	5,848 bp
Tssr62375	Chr6:106771148-106771158 (-)	5,885 bp
Tssr62374	Chr6:106768587-106768589 (-)	8,450 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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