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Crbn Gene Detail
Summary
  • Symbol
    Crbn
  • Name
    cereblon
  • Synonyms
    2610203G15Rik, 2900045O07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913277
    NCBI Gene: 58799
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:106757162-106777038 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 49.24 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    681 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913277
 protein coding gene Chr6:106755205-106777060 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031096
 protein coding gene Chr6:109016462-109036263 (-)
A/J MGP_AJ_G0031065
 protein coding gene Chr6:104843664-104864014 (-)
AKR/J MGP_AKRJ_G0030996
 protein coding gene Chr6:107681864-107704070 (-)
BALB/cJ MGP_BALBcJ_G0031076
 protein coding gene Chr6:104799234-104819298 (-)
C3H/HeJ MGP_C3HHeJ_G0030632
 protein coding gene Chr6:76636129-76656005 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031535
 protein coding gene Chr6:111854906-111874782 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028699
 protein coding gene Chr6:102307008-102327191 (-)
CAST/EiJ MGP_CASTEiJ_G0030183
 protein coding gene Chr6:108089954-108109864 (-)
CBA/J MGP_CBAJ_G0030762
 protein coding gene Chr6:116187695-116207987 (-)
DBA/2J MGP_DBA2J_G0030915
 protein coding gene Chr6:103979346-103999222 (-)
FVB/NJ MGP_FVBNJ_G0030869
 protein coding gene Chr6:103076941-103096922 (-)
LP/J MGP_LPJ_G0030995
 protein coding gene Chr6:109104770-109124571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030903
 protein coding gene Chr6:120449727-120471188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031562
 protein coding gene Chr6:107667081-107686957 (-)
PWK/PhJ MGP_PWKPhJ_G0029899
 protein coding gene Chr6:102980494-103000293 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029727
 protein coding gene Chr6:106496644-106516472 (-)
WSB/EiJ MGP_WSBEiJ_G0030267
 protein coding gene Chr6:108193681-108213718 (-)



Homology
more
  • Human Ortholog
    CRBN, cereblon
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRBN, cereblon
  • Synonyms
    MRT2, MRT2A
  • Links
    NCBI Gene ID: 51185
    neXtProt AC: NX_Q96SW2
    UniProt: Q96SW2

  • Chr Location
    3p26.2; chr3:3144628-3179727 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crbn mouse models; 1 with human CRBN associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired contextual conditioning behavior. Mice homozygous for another knock-out allele exhibit resistance to diet-induced obesity, liver steatosis, glucose intolerance and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    46
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005362 Ensembl Gene Model | MGI Sequence Detail 19877 C57BL/6J ±  kb
    transcript ENSMUST00000113239 Ensembl | MGI Sequence Detail 2084 Not Applicable  
    polypeptide ENSMUSP00000108865 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914412, MGI:1920153, MGI:2141645
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 9
      Phenotypes 43
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:352337 Costas-Insua C, et al., The CB(1) receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls. EMBO Mol Med. 2024 Apr;16(4):755-783
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory