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Psmd14 Gene Detail
Summary
  • Symbol
    Psmd14
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
  • Synonyms
    2610312C03Rik, 3200001M20Rik, Pad1, POH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913284
    NCBI Gene: 59029
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:61542038-61630720 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913284
 protein coding gene Chr2:61542038-61630720 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025766
 protein coding gene Chr2:61384140-61476455 (+)
A/J MGP_AJ_G0025742
 protein coding gene Chr2:59023355-59112585 (+)
AKR/J MGP_AKRJ_G0025712
 protein coding gene Chr2:60622223-60713326 (+)
BALB/cJ MGP_BALBcJ_G0025737
 protein coding gene Chr2:59128796-59222861 (+)
C3H/HeJ MGP_C3HHeJ_G0025498
 protein coding gene Chr2:60720449-60812427 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026184
 protein coding gene Chr2:63197103-63288282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023588
 protein coding gene Chr2:56524886-56615550 (+)
CAST/EiJ MGP_CASTEiJ_G0024962
 protein coding gene Chr2:60796662-60891193 (+)
CBA/J MGP_CBAJ_G0025478
 protein coding gene Chr2:65581824-65681503 (+)
DBA/2J MGP_DBA2J_G0025609
 protein coding gene Chr2:58596102-58689028 (+)
FVB/NJ MGP_FVBNJ_G0025571
 protein coding gene Chr2:58131690-58220201 (+)
LP/J MGP_LPJ_G0025697
 protein coding gene Chr2:61209068-61304157 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025602
 protein coding gene Chr2:67173701-67282726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026241
 protein coding gene Chr2:60663442-60754078 (+)
PWK/PhJ MGP_PWKPhJ_G0024703
 protein coding gene Chr2:58475559-58570265 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024510
 protein coding gene Chr2:60798561-60886029 (+)
WSB/EiJ MGP_WSBEiJ_G0025030
 protein coding gene Chr2:60992498-61088639 (+)



Homology
more
  • Human Ortholog
    PSMD14, proteasome 26S subunit, non-ATPase 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD14, proteasome 26S subunit, non-ATPase 14
  • Synonyms
    PAD1, POH1, RPN11
  • Links
    NCBI Gene ID: 10213
    neXtProt AC: NX_O00487
    UniProt: O00487

  • Chr Location
    2q24.2; chr2:161308425-161411717 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    18
  • cDNA Data
    164
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 59029 NCBI Gene Model | MGI Sequence Detail 88683 C57BL/6J ±  kb
transcript NM_021526 RefSeq | MGI Sequence Detail 1560 C57BL/6  
polypeptide O35593 UniProt | EBI | MGI Sequence Detail 310 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 165
    cDNA 165

    Microarray probesets 3
Other
Accession IDs
less
MGI:1915210, MGI:1919662, MGI:2138822
References
more
  • Summaries
    All 58
    Developmental Gene Expression 8
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:64935 Penney M, et al., The Pad1+ gene encodes a subunit of the 26 S proteasome in fission yeast. J Biol Chem. 1998 Sep 11;273(37):23938-45
  • Latest
    J:354019 Zhou B, et al., Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11. Cell Metab. 2024 Aug 9;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory