Ypel3 MGI Mouse Gene Detail - MGI:1913340

Symbol

Ypel3
Name

yippee like 3
Synonyms

0610043B10Rik, 1190001G19Rik, Suap

Feature Type

protein coding gene
IDs

MGI:1913340
NCBI Gene: 66090
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:126376135-126379682 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.25 cM, cytoband F4
Mapping Data

2 experiments

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913340	protein coding gene	Chr7:126376127-126379686 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032997	protein coding gene	Chr7:131075315-131078874 (+)
A/J	MGP_AJ_G0032980	protein coding gene	Chr7:127602718-127606279 (+)
AKR/J	MGP_AKRJ_G0032912	protein coding gene	Chr7:130836456-130840014 (+)
BALB/cJ	MGP_BALBcJ_G0032985	protein coding gene	Chr7:127264218-127267769 (+)
C3H/HeJ	MGP_C3HHeJ_G0032695	protein coding gene	Chr7:130774148-130777707 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033491	protein coding gene	Chr7:136169712-136173271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030463	protein coding gene	Chr7:128795119-128798700 (+)
CAST/EiJ	MGP_CASTEiJ_G0032024	protein coding gene	Chr7:122561049-122564611 (+)
CBA/J	MGP_CBAJ_G0032668	protein coding gene	Chr7:140753139-140756698 (+)
DBA/2J	MGP_DBA2J_G0032820	protein coding gene	Chr7:125576488-125580047 (+)
FVB/NJ	MGP_FVBNJ_G0032773	protein coding gene	Chr7:125423636-125428745 (+)
LP/J	MGP_LPJ_G0032914	protein coding gene	Chr7:132545681-132549240 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032805	protein coding gene	Chr7:141934430-141937988 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033510	protein coding gene	Chr7:129842561-129846122 (+)
PWK/PhJ	MGP_PWKPhJ_G0031731	protein coding gene	Chr7:118571426-118575020 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031577	protein coding gene	Chr7:116693541-116697096 (+)
WSB/EiJ	MGP_WSBEiJ_G0032136	protein coding gene	Chr7:130823236-130826797 (+)

Human Ortholog

YPEL3, yippee like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YPEL3, yippee like 3
Links

HGNC:18327

NCBI Gene ID: 83719

neXtProt AC: NX_P61236

UniProt: P61236
Chr Location

16p11.2; chr16:30092314-30096915 (-) GRCh38

MGI Vertebrate Homology

Ypel3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YPEL3
Gene Tree

Ypel3

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References

3 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

2
Targeted

7
Genomic Mutations

5 involving Ypel3
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

944
Tissues

54
cDNA Data

104
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ypel3

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All Sequences

68
RefSeq

14
UniProt

4
CCDS

CCDS21842.1

Ensembl

ENSMUSG00000042675 (Evidence)
NCBI Gene

66090

			Length	Strain/Species	Flank
genomic	66090	NCBI Gene Model \| MGI Sequence Detail	3548	C57BL/6J	± kb
transcript	NM_001379293	RefSeq \| MGI Sequence Detail	1173	C57BL/6
polypeptide	P61237	UniProt \| EBI \| MGI Sequence Detail	119	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017544 protein yippee-like 3

(term hierarchy)
InterPro Domains

IPR034751 Yippee domain

IPR039058 Yippee family

IPR004910 Yippee/Mis18/Cereblon

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All nucleic 105

cDNA 104

Primer pair 1

Microarray probesets 3

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MGI:1916180

Summaries

All 74

Developmental Gene Expression 2

Diseases 3

Gene Ontology 4

Phenotypes 46
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:349484 Henis M, et al., The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation. Sci Adv. 2024 Apr 12;10(15):eadf7001

TSS for Ypel3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69078	Chr7:126376111-126376176 (+)	9 bp
Tssr2396	Chr7:126376300-126376307 (+)	169 bp
Tssr2397	Chr7:126376329-126376350 (+)	205 bp
Tssr2398	Chr7:126376353-126376364 (+)	224 bp
Tssr69079	Chr7:126376938-126376970 (+)	819 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24