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Fmc1 Gene Detail
Summary
  • Symbol
    Fmc1
  • Name
    formation of mitochondrial complex V assembly factor 1
  • Synonyms
    1110001J03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913367
    NCBI Gene: 66117
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:38511796-38516384 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 17.84 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913367
protein coding gene Chr6:38510437-38516384 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030587
protein coding gene Chr6:36858832-36864779 (+)
A/J MGP_AJ_G0030560
protein coding gene Chr6:35246516-35252463 (+)
AKR/J MGP_AKRJ_G0030487
protein coding gene Chr6:36371173-36377120 (+)
BALB/cJ MGP_BALBcJ_G0030570
protein coding gene Chr6:35447358-35454394 (+)
C3H/HeJ MGP_C3HHeJ_G0030283
protein coding gene Chr6:36382693-36388640 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031024
protein coding gene Chr6:37774609-37780556 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028236
protein coding gene Chr6:33151959-33158000 (+)
CAST/EiJ MGP_CASTEiJ_G0029685
protein coding gene Chr6:36274245-36280232 (+)
CBA/J MGP_CBAJ_G0030261
protein coding gene Chr6:39237392-39243561 (+)
DBA/2J MGP_DBA2J_G0030405
protein coding gene Chr6:35065293-35071240 (+)
FVB/NJ MGP_FVBNJ_G0030359
protein coding gene Chr6:34855247-34861194 (+)
LP/J MGP_LPJ_G0030492
protein coding gene Chr6:36889094-36895263 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030395
protein coding gene Chr6:41603261-41609208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031054
protein coding gene Chr6:36303174-36309343 (+)
PWK/PhJ MGP_PWKPhJ_G0029399
protein coding gene Chr6:34730372-34736310 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029235
protein coding gene Chr6:36026960-36032851 (+)
WSB/EiJ MGP_WSBEiJ_G0029761
protein coding gene Chr6:36242055-36248002 (+)



Homology
more
  • Human Ortholog
    FMC1, formation of mitochondrial complex V assembly factor 1 homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FMC1, formation of mitochondrial complex V assembly factor 1 homolog
  • Synonyms
    C7orf55, HSPC268
  • Links
    NCBI Gene ID: 154791
    neXtProt AC: NX_Q96HJ9
    UniProt: Q96HJ9

  • Chr Location
    7q34; chr7:139339457-139346328 (+)  GRCh38

  • Human Ortholog
    FMC1-LUC7L2, FMC1-LUC7L2 readthrough
  • Synonyms
    C7orf55, C7orf55-LUC7L2, FMC1
  • Links
    NCBI Gene ID: 100996928
    neXtProt AC: NX_Q96HJ9

  • Chr Location
    7q34; chr7:139341337-139423454 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality. Mice heterozygous for a null allele exhibit resistance to MPTP-induced parkinsonism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66117 NCBI Gene Model | MGI Sequence Detail 4589 C57BL/6J ±  kb
    transcript NM_025363 RefSeq | MGI Sequence Detail 441 C57BL/6  
    polypeptide Q9CR13 UniProt | EBI | MGI Sequence Detail 113 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR037667 Protein FMC1 homologue
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349932 Cater RJ, et al., Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature. 2024 May;629(8012):704-709

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory