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Eef1e1 Gene Detail
Summary
  • Symbol
    Eef1e1
  • Name
    eukaryotic translation elongation factor 1 epsilon 1
  • Synonyms
    1110003A02Rik, AIMP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913393
    NCBI Gene: 66143
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:38829667-38843004 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 18.38 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    430 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913393
 protein coding gene Chr13:38828183-38843034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020475
 protein coding gene Chr13:37010961-37025536 (-)
A/J MGP_AJ_G0020429
 protein coding gene Chr13:35824460-35837616 (-)
AKR/J MGP_AKRJ_G0020407
 protein coding gene Chr13:36777787-36790874 (-)
BALB/cJ MGP_BALBcJ_G0020425
 protein coding gene Chr13:35926206-35939362 (-)
C3H/HeJ MGP_C3HHeJ_G0020224
 protein coding gene Chr13:36611068-36624206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020858
 protein coding gene Chr13:38217754-38230862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018445
 protein coding gene Chr13:34010167-34021039 (-)
CAST/EiJ MGP_CASTEiJ_G0019739
 protein coding gene Chr13:36392171-36402824 (-)
CBA/J MGP_CBAJ_G0020185
 protein coding gene Chr13:39837569-39850726 (-)
DBA/2J MGP_DBA2J_G0020307
 protein coding gene Chr13:35343498-35356661 (-)
FVB/NJ MGP_FVBNJ_G0020286
 protein coding gene Chr13:34873043-34886171 (-)
LP/J MGP_LPJ_G0020382
 protein coding gene Chr13:37253843-37266974 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0020901
 protein coding gene Chr13:36341254-36354402 (-)
PWK/PhJ MGP_PWKPhJ_G0019494
 protein coding gene Chr13:35471756-35484974 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019801
 protein coding gene Chr13:36702102-36715241 (-)



Homology
more
  • Human Ortholog
    EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF1E1, eukaryotic translation elongation factor 1 epsilon 1
  • Synonyms
    AIMP3, P18
  • Links
    NCBI Gene ID: 9521
    neXtProt AC: NX_O43324
    UniProt: O43324

  • Chr Location
    6p24.3; chr6:8073360-8102559 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display early embryonic lethality while heterozygous mice exhibit prenatal semi-lethality and a significantly increased incidence of spontaneous tumorigenesis after 15 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    33
  • cDNA Data
    45
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66143 NCBI Gene Model | MGI Sequence Detail 13338 C57BL/6J ±  kb
transcript NM_025380 RefSeq | MGI Sequence Detail 1039 C57BL/6  
polypeptide Q9D1M4 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006907 eukaryotic translation elongation factor 1 epsilon-1
    (term hierarchy)
  • InterPro Domains
    IPR042450 Eukaryotic translation elongation factor 1 epsilon-1
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
Molecular
Reagents
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  • All nucleic 46
    cDNA 45
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:274587 Kotov DI, et al., TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2. J Immunol. 2019 May 1;202(9):2535-2545
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory