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Tmem14c Gene Detail
Summary
  • Symbol
    Tmem14c
  • Name
    transmembrane protein 14C
  • Synonyms
    1110021D01Rik, HSPC194
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913404
    NCBI Gene: 66154
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:41169768-41176062 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913404
 protein coding gene Chr13:41169726-41176062 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020482
 protein coding gene Chr13:39496777-39504739 (+)
A/J MGP_AJ_G0020436
 protein coding gene Chr13:38173737-38180099 (+)
AKR/J MGP_AKRJ_G0020414
 protein coding gene Chr13:39216950-39223280 (+)
BALB/cJ MGP_BALBcJ_G0020432
 protein coding gene Chr13:38363013-38369597 (+)
C3H/HeJ MGP_C3HHeJ_G0020231
 protein coding gene Chr13:39096500-39105943 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020865
 protein coding gene Chr13:40751622-40757925 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018452
 protein coding gene Chr13:36313924-36320427 (+)
CAST/EiJ MGP_CASTEiJ_G0019746
 protein coding gene Chr13:38871306-38877754 (+)
CBA/J MGP_CBAJ_G0020192
 protein coding gene Chr13:42502271-42508500 (+)
DBA/2J MGP_DBA2J_G0020314
 protein coding gene Chr13:37753079-37759728 (+)
FVB/NJ MGP_FVBNJ_G0020293
 protein coding gene Chr13:37248511-37255042 (+)
LP/J MGP_LPJ_G0020389
 protein coding gene Chr13:39738360-39745363 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020322
 protein coding gene Chr13:42469969-42477402 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020908
 protein coding gene Chr13:38865220-38873869 (+)
PWK/PhJ MGP_PWKPhJ_G0019501
 protein coding gene Chr13:37814732-37821814 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019331
 protein coding gene Chr13:37474229-37480704 (+)
WSB/EiJ MGP_WSBEiJ_G0019808
 protein coding gene Chr13:39167711-39174165 (+)



Homology
more
  • Human Ortholog
    TMEM14B, transmembrane protein 14B
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM14B, transmembrane protein 14B
  • Links
    NCBI Gene ID: 81853
    neXtProt AC: NX_Q9NUH8
    UniProt: Q9NUH8

  • Chr Location
    6p24.2; chr6:10747759-10852753 (+)  GRCh38
  • Human Ortholog
    TMEM14C, transmembrane protein 14C
  • Synonyms
    bA421M1.6, C6orf53, HSPC194, MSTP073, NET26
  • Links
    NCBI Gene ID: 51522
    neXtProt AC: NX_Q9P0S9
    UniProt: Q9P0S9

  • Chr Location
    6p24.2; chr6:10722915-10731129 (+)  GRCh38
  • Human Ortholog
    TMEM14DP, transmembrane protein 14D, pseudogene
  • Synonyms
    bA524O24.3, TMEM14D
  • Links
    NCBI Gene ID: 645203
    UniProt: A8MWL7

  • Chr Location
    10q21.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit porphyrin accumulation in fetal liver, erythroid maturation arrest, and embryonic lethality due to severe anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    967
  • Tissues
    88
  • cDNA Data
    173
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021361 Ensembl Gene Model | MGI Sequence Detail 6295 C57BL/6J ±  kb
    transcript ENSMUST00000021790 Ensembl | MGI Sequence Detail 914 Not Applicable  
    polypeptide ENSMUSP00000021790 Ensembl | MGI Sequence Detail 114 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 175
      cDNA 173
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145355
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory