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Sptssb Gene Detail
Summary
  • Symbol
    Sptssb
  • Name
    serine palmitoyltransferase, small subunit B
  • Synonyms
    1110032A04Rik, ADMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913433
    NCBI Gene: 66183
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:69726875-69767273 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.30 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    988 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913433
 protein coding gene Chr3:69726871-69768697 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027298
 protein coding gene Chr3:69092944-69128606 (-)
A/J MGP_AJ_G0027260
 protein coding gene Chr3:67011923-67066234 (-)
AKR/J MGP_AKRJ_G0027228
 protein coding gene Chr3:68474257-68515993 (-)
BALB/cJ MGP_BALBcJ_G0027271
 protein coding gene Chr3:66908008-66946194 (-)
C3H/HeJ MGP_C3HHeJ_G0027015
 protein coding gene Chr3:68702608-68738653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027717
 protein coding gene Chr3:71672159-71714862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025070
 protein coding gene Chr3:63283270-63316720 (-)
CAST/EiJ MGP_CASTEiJ_G0026462
 protein coding gene Chr3:68686551-68724741 (-)
CBA/J MGP_CBAJ_G0026990
 protein coding gene Chr3:73891731-73929891 (-)
DBA/2J MGP_DBA2J_G0027126
 protein coding gene Chr3:66508442-66544915 (-)
FVB/NJ MGP_FVBNJ_G0027094
 protein coding gene Chr3:65140208-65172099 (-)
LP/J MGP_LPJ_G0027234
 protein coding gene Chr3:70039198-70074391 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027113
 protein coding gene Chr3:78502248-78541432 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027775
 protein coding gene Chr3:68350833-68386020 (-)
PWK/PhJ MGP_PWKPhJ_G0026196
 protein coding gene Chr3:66279174-66318551 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026012
 protein coding gene Chr3:67453825-67489506 (-)
WSB/EiJ MGP_WSBEiJ_G0026540
 protein coding gene Chr3:68490662-68530787 (-)



Homology
more
  • Human Ortholog
    SPTSSB, serine palmitoyltransferase small subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPTSSB, serine palmitoyltransferase small subunit B
  • Synonyms
    ADMP, C3orf57, SSSPTB
  • Links
    NCBI Gene ID: 165679
    neXtProt AC: NX_Q8NFR3
    UniProt: Q8NFR3

  • Chr Location
    3q26.1; chr3:161344798-161372880 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for an ENU mutation exhibit shiny flecks in the ocular fundus and brain vacuoles. Mice homozygous for the allele exhibit premature death, ataxia, decreased weight, shiny flecks in the ocular fundus, brain and retina vacuoles and impaired ER stress response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    14
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043461 Ensembl Gene Model | MGI Sequence Detail 40399 C57BL/6J ±  kb
    transcript ENSMUST00000051239 Ensembl | MGI Sequence Detail 1795 Not Applicable  
    polypeptide ENSMUSP00000062794 Ensembl | MGI Sequence Detail 76 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 5
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory