About   Help   FAQ
Acer3 Gene Detail
Summary
  • Symbol
    Acer3
  • Name
    alkaline ceramidase 3
  • Synonyms
    1110057L18Rik, 5430429L08Rik, Phca
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913440
    NCBI Gene: 66190
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:97863015-97970415 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.65 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2221 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913440
 protein coding gene Chr7:97855596-97970415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032537
 protein coding gene Chr7:100943661-101027699 (-)
A/J MGP_AJ_G0032511
 protein coding gene Chr7:98449680-98537175 (-)
AKR/J MGP_AKRJ_G0032447
 protein coding gene Chr7:100790482-100879340 (-)
BALB/cJ MGP_BALBcJ_G0032522
 protein coding gene Chr7:98138507-98227782 (-)
C3H/HeJ MGP_C3HHeJ_G0032237
 protein coding gene Chr7:101145945-101234091 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033020
 protein coding gene Chr7:104858278-104951930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030015
 protein coding gene Chr7:100899371-100980094 (-)
CAST/EiJ MGP_CASTEiJ_G0031564
 protein coding gene Chr7:92662097-92752708 (-)
CBA/J MGP_CBAJ_G0032204
 protein coding gene Chr7:108415453-108523229 (-)
DBA/2J MGP_DBA2J_G0032356
 protein coding gene Chr7:96785084-96867588 (-)
FVB/NJ MGP_FVBNJ_G0032312
 protein coding gene Chr7:96589171-96672244 (-)
LP/J MGP_LPJ_G0032445
 protein coding gene Chr7:102267551-102357245 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032345
 protein coding gene Chr7:109953078-110058792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033042
 protein coding gene Chr7:100065044-100150096 (-)
PWK/PhJ MGP_PWKPhJ_G0031282
 protein coding gene Chr7:89861615-89954678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031125
 protein coding gene Chr7:87322263-87422683 (-)
WSB/EiJ MGP_WSBEiJ_G0031681
 protein coding gene Chr7:100714433-100810215 (-)



Homology
more
  • Human Ortholog
    ACER3, alkaline ceramidase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACER3, alkaline ceramidase 3
  • Synonyms
    APHC, PHCA, PLDECO
  • Links
    NCBI Gene ID: 55331
    neXtProt AC: NX_Q9NUN7
    UniProt: Q9NUN7

  • Chr Location
    11q13.5; chr11:76860859-77026797 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered homeostasis of ceramides and their sphingolipid derivatives in the aging brain resulting in Purkinje cell degeneration, decreased vertical activity, limb grasping, and impaired motor coordination and balance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    98
  • cDNA Data
    22
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66190 NCBI Gene Model | MGI Sequence Detail 107401 C57BL/6J ±  kb
transcript NM_001360617 RefSeq | MGI Sequence Detail 4087 C57BL/6  
polypeptide Q9D099 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918651, MGI:2142169
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory