Cks2 MGI Mouse Gene Detail - MGI:1913447 - CDC28 protein kinase regulatory subunit 2

Symbol

Cks2
Name

CDC28 protein kinase regulatory subunit 2
Synonyms

1110038L14Rik, CKSHS2

Feature Type

protein coding gene
IDs

MGI:1913447
NCBI Gene: 66197
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr13:51799268-51804696 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 26.12 cM
Mapping Data

1 experiment

SNPs within 2kb

200 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913447	protein coding gene	Chr13:51799268-51804698 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020551	protein coding gene	Chr13:50866260-50873720 (+)
A/J	MGP_AJ_G0020505	protein coding gene	Chr13:49064461-49069889 (+)
AKR/J	MGP_AKRJ_G0020483	protein coding gene	Chr13:50457166-50464260 (+)
BALB/cJ	MGP_BALBcJ_G0020501	protein coding gene	Chr13:49252839-49258267 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0020935	protein coding gene	Chr13:52435738-52441059 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018517	protein coding gene	Chr13:46862212-46867613 (+)
CAST/EiJ	MGP_CASTEiJ_G0019814	protein coding gene	Chr13:50258599-50265702 (+)
CBA/J	MGP_CBAJ_G0020260	protein coding gene	Chr13:54467384-54472833 (+)
DBA/2J	MGP_DBA2J_G0020383	protein coding gene	Chr13:48631125-48637381 (+)
FVB/NJ	MGP_FVBNJ_G0020362	protein coding gene	Chr13:48059957-48065502 (+)
LP/J	MGP_LPJ_G0020459	protein coding gene	Chr13:51136981-51144063 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020391	protein coding gene	Chr13:54062294-54070978 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020978	protein coding gene	Chr13:50029845-50037470 (+)
PWK/PhJ	MGP_PWKPhJ_G0019571	protein coding gene	Chr13:48552318-48558020 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019398	protein coding gene	Chr13:48918028-48924382 (+)
WSB/EiJ	MGP_WSBEiJ_G0019876	protein coding gene	Chr13:50340553-50345968 (+)

Human Ortholog

CKS2, CDC28 protein kinase regulatory subunit 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CKS2, CDC28 protein kinase regulatory subunit 2
Synonyms

CKSHS2
Links

HGNC:2000

NCBI Gene ID: 1164

neXtProt AC: NX_P33552

UniProt: P33552
Chr Location

9q22.2; chr9:89311195-89316703 (+) GRCh38

MGI Vertebrate Homology

Cks2 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: CKS2
Gene Tree

Cks2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Gene trapped

47
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Cks2
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase.

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

11
cDNA Data

94
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cks2

ZFIN cks2

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS36664.1

Ensembl

ENSMUSG00000062248 (Evidence)
NCBI Gene

66197

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062248	Ensembl Gene Model \| MGI Sequence Detail	5429	C57BL/6J	± kb
transcript	ENSMUST00000075853	Ensembl \| MGI Sequence Detail	692	Not Applicable
polypeptide	ENSMUSP00000075250	Ensembl \| MGI Sequence Detail	79	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005519 cyclin-dependent kinases regulatory subunit 2

(term hierarchy)
InterPro Domains

IPR000789 Cyclin-dependent kinase, regulatory subunit

IPR036858 Cyclin-dependent kinase, regulatory subunit superfamily

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All nucleic 96

cDNA 94

Primer pair 2

Microarray probesets 7

Summaries

All 46

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:290356 Ellederova Z, et al., CKS1 Germ Line Exclusion Is Essential for the Transition from Meiosis to Early Embryonic Development. Mol Cell Biol. 2019 Jul 1;39(13)

TSS for Cks2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119759	Chr13:51799304-51799312 (+)	40 bp
Tssr119760	Chr13:51799320-51799335 (+)	60 bp
Tssr119761	Chr13:51799346-51799368 (+)	89 bp
Tssr119762	Chr13:51799406-51799428 (+)	149 bp
Tssr119763	Chr13:51799728-51799763 (+)	478 bp
Tssr119764	Chr13:51799772-51799783 (+)	510 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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