Thoc7 MGI Mouse Gene Detail - MGI:1913481

Symbol

Thoc7
Name

THO complex 7
Synonyms

1500006O09Rik, 9230101K24Rik

Feature Type

protein coding gene
IDs

MGI:1913481
NCBI Gene: 66231
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:8507911-8520751 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 7.08 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

458 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913481	protein coding gene	Chr14:8507911-8520751 (+)
129S1/SvImJ	ENSMUSG00200025145	protein coding gene	Chr14:5146622-5159566 (+)
A/J	ENSMUSG00195029825	protein coding gene	Chr14:5971110-5984129 (+)
AKR/J	ENSMUSG00220022863	protein coding gene	Chr14:5131244-5144264 (+)
BALB/cJ	ENSMUSG00180021984	protein coding gene	Chr14:5296258-5309261 (+)
C3H/HeJ	ENSMUSG00175008880	protein coding gene	Chr14:5290783-5303727 (+)
C57BL/6NJ	ENSMUSG00215011738	protein coding gene	Chr14:5550903-5563753 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018957	protein coding gene	Chr14:6968170-6980469 (-)
CAST/EiJ	ENSTCUG00005030437	protein coding gene	Chr14:5212795-5225897 (+)
CBA/J	ENSMUSG00210033180	protein coding gene	Chr14:5513092-5526035 (+)
DBA/2J	ENSMUSG00185036276	protein coding gene	Chr14:5518970-5531914 (+)
FVB/NJ	ENSMUSG00205020061	protein coding gene	Chr14:5513156-5526007 (+)
JF1/MsJ	ENSUMUG00000018129	protein coding gene	Chr14:5527387-5540308 (+)
LP/J	ENSMUSG00230006105	protein coding gene	Chr14:6647122-6660830 (+)
NOD/ShiLtJ	ENSMUSG00190026040	protein coding gene	Chr14:5542951-5555800 (+)
NZO/HlLtJ	ENSMUSG00225036706	protein coding gene	Chr14:5943970-5956969 (+)
PWK/PhJ	ENSLUMG00010030274	protein coding gene	Chr14:26854954-26867992 (+)
SPRET/EiJ	ENSMSPG00010002310	protein coding gene	Chr14:5825057-5838004 (+)
WSB/EiJ	ENSIUOG00005024105	protein coding gene	Chr14:5373214-5386247 (+)

Human Ortholog

THOC7, THO complex subunit 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THOC7, THO complex subunit 7
Synonyms

fSAP24, hTREX30, NIF3L1BP1
Links

HGNC:29874

NCBI Gene ID: 80145

UniProt: Q6I9Y2
Chr Location

3p14.1; chr3:63833870-63864484 (-) GRCh38

MGI Vertebrate Homology

Thoc7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THOC7
Gene Tree

Thoc7

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
1 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

635
Tissues

5
cDNA Data

21
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thoc7

ZFIN thoc7

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All Sequences

137
RefSeq

71
UniProt

4
CCDS

CCDS49403.1, CCDS88568.1

Ensembl

ENSMUSG00000053453 (Evidence)
NCBI Gene

66231

			Length	Strain/Species	Flank
genomic	66231	NCBI Gene Model \| MGI Sequence Detail	12841	C57BL/6J	± kb
transcript	NM_001426030	RefSeq \| MGI Sequence Detail	1277	C57BL/6
polypeptide	Q7TMY4	UniProt \| EBI \| MGI Sequence Detail	204	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016316 THO complex subunit 7

(term hierarchy)
InterPro Domains

IPR008501 THO complex subunit 7/Mft1

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All nucleic 21

cDNA 21

Microarray probesets 5

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MGI:2444366

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Thoc7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127490	Chr14:8507876-8507904 (+)	-21 bp
Tssr127489	Chr14:8507905-8507918 (+)	1 bp
Tssr127488	Chr14:8508123-8508137 (+)	219 bp
Tssr127487	Chr14:8508321-8508385 (+)	442 bp
Tssr127486	Chr14:8508460-8508471 (+)	555 bp
Tssr127485	Chr14:8508485-8508561 (+)	612 bp
Tssr127484	Chr14:8508564-8508577 (+)	660 bp
Tssr127483	Chr14:8514734-8514737 (+)	6,825 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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