Atp6v1g2 MGI Mouse Gene Detail - MGI:1913487 - ATPase, H+ transporting, lysosomal V1 subunit G2

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Atp6v1g2 Gene Detail

Symbol

Atp6v1g2
Name

ATPase, H+ transporting, lysosomal V1 subunit G2
Synonyms

1500002D01Rik, Atp6g2, lysosomal 13kDa, NG38, VAG2

Feature Type

protein coding gene
IDs

MGI:1913487
NCBI Gene: 66237
Alliance

gene page
Transcription Start Sites

20 TSS

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Sequence Map

Chr17:35453910-35457743 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.60 cM, cytoband B2
Mapping Data

2 experiments

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Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1913487	protein coding gene	Chr17:35452636-35457743 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023632	protein coding gene	Chr17:35385128-35390235 (+)
A/J	MGP_AJ_G0023591	protein coding gene	Chr17:34203849-34208927 (+)
AKR/J	MGP_AKRJ_G0023560	protein coding gene	Chr17:34683963-34689068 (+)
BALB/cJ	MGP_BALBcJ_G0023598	protein coding gene	Chr17:34349339-34354417 (+)
C3H/HeJ	MGP_C3HHeJ_G0023359	protein coding gene	Chr17:35089352-35094457 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024037	protein coding gene	Chr17:36740528-36745635 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021518	protein coding gene	Chr17:31976246-31981331 (+)
CAST/EiJ	MGP_CASTEiJ_G0022855	protein coding gene	Chr17:35098415-35103519 (+)
CBA/J	MGP_CBAJ_G0023337	protein coding gene	Chr17:38242530-38247635 (+)
DBA/2J	MGP_DBA2J_G0023465	protein coding gene	Chr17:33531115-33536193 (+)
FVB/NJ	MGP_FVBNJ_G0023432	protein coding gene	Chr17:33373205-33378308 (+)
LP/J	MGP_LPJ_G0023542	protein coding gene	Chr17:35714470-35719577 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023454	protein coding gene	Chr17:37169912-37175019 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024082	protein coding gene	Chr17:34914233-34919332 (+)
PWK/PhJ	MGP_PWKPhJ_G0022603	protein coding gene	Chr17:32372161-32377264 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022423	protein coding gene	Chr17:32923083-32928135 (+)
WSB/EiJ	MGP_WSBEiJ_G0022919	protein coding gene	Chr17:35043293-35048409 (+)

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Human Ortholog

ATP6V1G2, ATPase H+ transporting V1 subunit G2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP6V1G2, ATPase H+ transporting V1 subunit G2
Synonyms

ATP6G, ATP6G2, NG38, VMA10
Links

HGNC:862

NCBI Gene ID: 534

neXtProt AC: NX_O95670

UniProt: O95670
Chr Location

6p21.33; chr6:31544444-31548427 (-) GRCh38

MGI Vertebrate Homology

Atp6v1g2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ATP6V1G2
Gene Tree

Atp6v1g2

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

5
Targeted

4
Genomic Mutations

1 involving Atp6v1g2
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele are produced in the expected ratio.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

917
Tissues

131
cDNA Data

35
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp6v1g2

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All Sequences

48
RefSeq

6
UniProt

4
CCDS

CCDS37597.1, CCDS84301.1

Ensembl

ENSMUSG00000024403 (Evidence)
NCBI Gene

66237

Representative Sequences				Length	Strain/Species	Flank
	genomic	66237	NCBI Gene Model \| MGI Sequence Detail	3834	C57BL/6J	± kb
	transcript	NM_001347351	RefSeq \| MGI Sequence Detail	1584	C57BL/6
	polypeptide	Q9WTT4	UniProt \| EBI \| MGI Sequence Detail	118	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004490 V-type proton ATPase subunit G 2

(term hierarchy)
PDB

9BRA, 9BRQ, 9BRR, 9BRS, 9BRT, 9BRU
InterPro Domains

IPR005124 Vacuolar (H+)-ATPase G subunit
GlyGen

Q9WTT4 1 site, 1 N-linked glycan (1 site)

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All nucleic 38

cDNA 36

Other 2

Microarray probesets 3

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Summaries

All 44

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 14
Earliest

J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp6v1g2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144298	Chr17:35451981-35451990 (+)	-1,924 bp
Tssr144299	Chr17:35454063-35454087 (+)	165 bp
Tssr144300	Chr17:35454833-35454866 (+)	940 bp
Tssr144301	Chr17:35454873-35454889 (+)	971 bp
Tssr144302	Chr17:35455532-35455583 (+)	1,648 bp
Tssr144303	Chr17:35455584-35455593 (+)	1,679 bp
Tssr144304	Chr17:35455626-35455644 (+)	1,725 bp
Tssr144305	Chr17:35455646-35455655 (+)	1,741 bp
Tssr5102	Chr17:35455660-35455669 (+)	1,755 bp
Tssr144306	Chr17:35455671-35455735 (+)	1,793 bp
Tssr144307	Chr17:35456649-35456669 (+)	2,749 bp
Tssr144308	Chr17:35456735-35456753 (+)	2,834 bp
Tssr144309	Chr17:35456786-35456798 (+)	2,882 bp
Tssr144310	Chr17:35456871-35456894 (+)	2,973 bp
Tssr144311	Chr17:35456899-35456910 (+)	2,995 bp
Tssr144312	Chr17:35456941-35456957 (+)	3,039 bp
Tssr144313	Chr17:35456961-35456986 (+)	3,064 bp
Tssr144314	Chr17:35457143-35457157 (+)	3,240 bp
Tssr144315	Chr17:35457318-35457347 (+)	3,423 bp
Tssr144316	Chr17:35457354-35457380 (+)	3,457 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24