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Kcne5 Gene Detail
Summary
  • Symbol
    Kcne5
  • Name
    potassium voltage-gated channel subfamily E regulatory subunit 5
  • Synonyms
    1500015C14Rik, Kcne1l, Kcne5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913490
    NCBI Gene: 66240
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:141087749-141089194 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 63.11 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913490
 protein coding gene ChrX:141087748-141089290 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036149
 protein coding gene ChrX:139799476-139801018 (-)
A/J MGP_AJ_G0036126
 protein coding gene ChrX:139204486-139206028 (-)
AKR/J MGP_AKRJ_G0036052
 protein coding gene ChrX:143652653-143654195 (-)
BALB/cJ MGP_BALBcJ_G0036117
 protein coding gene ChrX:137436176-137437718 (-)
C3H/HeJ MGP_C3HHeJ_G0035825
 protein coding gene ChrX:139905299-139906841 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036640
 protein coding gene ChrX:143819482-143821024 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033464
 protein coding gene ChrX:130771426-130772966 (-)
CAST/EiJ MGP_CASTEiJ_G0035116
 protein coding gene ChrX:120625819-120627361 (-)
CBA/J MGP_CBAJ_G0035802
 protein coding gene ChrX:148307234-148308776 (-)
DBA/2J MGP_DBA2J_G0035960
 protein coding gene ChrX:138270955-138272497 (-)
FVB/NJ MGP_FVBNJ_G0035894
 protein coding gene ChrX:137497980-137499522 (-)
LP/J MGP_LPJ_G0036051
 protein coding gene ChrX:140761573-140763115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035930
 protein coding gene ChrX:155941967-155943509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036677
 protein coding gene ChrX:139110456-139111998 (-)
PWK/PhJ MGP_PWKPhJ_G0034810
 protein coding gene ChrX:117437851-117439393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034635
 protein coding gene ChrX:121134553-121136095 (-)
WSB/EiJ MGP_WSBEiJ_G0035251
 protein coding gene ChrX:137504094-137505636 (-)



Homology
more
  • Human Ortholog
    KCNE5, potassium voltage-gated channel subfamily E regulatory subunit 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNE5, potassium voltage-gated channel subfamily E regulatory subunit 5
  • Synonyms
    KCNE1L
  • Links
    NCBI Gene ID: 23630
    neXtProt AC: NX_Q9UJ90
    UniProt: Q9UJ90

  • Chr Location
    Xq23; chrX:109623700-109625172 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for null alleles show ventricular arrhythmia (ventricular premature beat), increased susceptibility to induction of polymorphic ventricular tachycardia, shorter ventricular refractory period, and augmented ventricular potassium currents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    24
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66240 NCBI Gene Model | MGI Sequence Detail 1446 C57BL/6J ±  kb
    transcript NM_021487 RefSeq | MGI Sequence Detail 1446 Not Specified  
    polypeptide Q9QZ26 UniProt | EBI | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000031113 potassium voltage-gated channel subfamily E regulatory beta subunit 5
      (term hierarchy)
    • InterPro Domains
      IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:57928 Piccini M, et al., KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs. Genomics. 1999 Sep 15;60(3):251-7
    • Latest
      J:313609 Diaz Del Moral S, et al., Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021;9:683861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    07/02/2024
    MGI 6.13     		The Jackson Laboratory