Alg5 MGI Mouse Gene Detail - MGI:1913498 - ALG5 dolichyl-phosphate beta-glucosyltransferase

Symbol

Alg5
Name

ALG5 dolichyl-phosphate beta-glucosyltransferase
Synonyms

1500026A19Rik, 2600005J22Rik

Feature Type

protein coding gene
IDs

MGI:1913498
NCBI Gene: 66248
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:54642960-54657216 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 25.60 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913498	protein coding gene	Chr3:54642960-54658739 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027215	protein coding gene	Chr3:53437274-53454910 (+)
A/J	MGP_AJ_G0027175	protein coding gene	Chr3:51791437-51807345 (+)
AKR/J	MGP_AKRJ_G0027145	protein coding gene	Chr3:52850218-52867466 (+)
BALB/cJ	MGP_BALBcJ_G0027188	protein coding gene	Chr3:51642851-51658784 (+)
C3H/HeJ	MGP_C3HHeJ_G0026931	protein coding gene	Chr3:53062486-53080675 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027634	protein coding gene	Chr3:55471886-55492303 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024993	protein coding gene	Chr3:48312732-48328664 (+)
CAST/EiJ	MGP_CASTEiJ_G0026383	protein coding gene	Chr3:53199326-53217010 (+)
CBA/J	MGP_CBAJ_G0026907	protein coding gene	Chr3:57241750-57269694 (+)
DBA/2J	MGP_DBA2J_G0027041	protein coding gene	Chr3:51351255-51366978 (+)
FVB/NJ	MGP_FVBNJ_G0027009	protein coding gene	Chr3:50322615-50344416 (+)
LP/J	MGP_LPJ_G0027153	protein coding gene	Chr3:54139365-54157339 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027027	protein coding gene	Chr3:61349682-61368254 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027692	protein coding gene	Chr3:52769025-52787231 (+)
PWK/PhJ	MGP_PWKPhJ_G0026115	protein coding gene	Chr3:51025714-51041752 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025928	protein coding gene	Chr3:52527769-52544992 (+)
WSB/EiJ	MGP_WSBEiJ_G0026457	protein coding gene	Chr3:52898967-52915995 (+)

Human Ortholog

ALG5, ALG5 dolichyl-phosphate beta-glucosyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALG5, ALG5 dolichyl-phosphate beta-glucosyltransferase
Synonyms

bA421P11.2, PKD7
Links

HGNC:20266

NCBI Gene ID: 29880

neXtProt AC: NX_Q9Y673

UniProt: Q9Y673
Chr Location

13q13.3; chr13:36949738-37000763 (-) GRCh38

MGI Vertebrate Homology

Alg5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALG5
Gene Tree

Alg5

Diseases

1 with human ALG5 associations

				Human Disease	Mouse Models
				polycystic kidney disease 7 IDs polycystic kidney disease 7 DOID:0060952 OMIM:620056

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (ENU)

1
Gene trapped

18
Radiation induced

2
Genomic Mutations

2 involving Alg5
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available

Embryos homozygous for an ENU-induced mutation arrest unturned at E9.5 and display no left-right asymmetry.

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alg5

ZFIN alg5

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS17353.1

Ensembl

ENSMUSG00000036632 (Evidence)
NCBI Gene

66248

			Length	Strain/Species	Flank
genomic	66248	NCBI Gene Model \| MGI Sequence Detail	14257	C57BL/6J	± kb
transcript	NM_025442	RefSeq \| MGI Sequence Detail	1471	C57BL/6
polypeptide	Q9DB25	UniProt \| EBI \| MGI Sequence Detail	324	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003945 dolichyl-phosphate beta-glucosyltransferase

(term hierarchy)
EC

2.4.1.117
InterPro Domains

IPR035518 Dolichyl-phosphate beta-glucosyltransferase

IPR001173 Glycosyltransferase 2-like

IPR029044 Nucleotide-diphospho-sugar transferases

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All nucleic 13

cDNA 13

Microarray probesets 5

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MGI:1919365, MGI:2139924, MGI:2139938, MGI:2139996

Summaries

All 34

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 11
Earliest

J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Alg5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29139	Chr3:54642957-54643007 (+)	22 bp
Tssr29140	Chr3:54651916-54651932 (+)	8,964 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24