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Camk2n1 Gene Detail
Summary
  • Symbol
    Camk2n1
  • Name
    calcium/calmodulin-dependent protein kinase II inhibitor 1
  • Synonyms
    1810006K23Rik, CaMKIINalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913509
    NCBI Gene: 66259
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138182459-138187437 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913509
 protein coding gene Chr4:138181625-138187437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028998
 protein coding gene Chr4:141199837-141207333 (+)
A/J MGP_AJ_G0028957
 protein coding gene Chr4:135156525-135162358 (+)
AKR/J MGP_AKRJ_G0028909
 protein coding gene Chr4:139017450-139023283 (+)
BALB/cJ MGP_BALBcJ_G0028981
 protein coding gene Chr4:135830922-135838081 (+)
C3H/HeJ MGP_C3HHeJ_G0028695
 protein coding gene Chr4:139380946-139389232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029422
 protein coding gene Chr4:146206762-146212487 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026693
 protein coding gene Chr4:128135545-128141379 (+)
CAST/EiJ MGP_CASTEiJ_G0028127
 protein coding gene Chr4:137545914-137551713 (+)
CBA/J MGP_CBAJ_G0028660
 protein coding gene Chr4:150386105-150394544 (+)
DBA/2J MGP_DBA2J_G0028809
 protein coding gene Chr4:135541562-135547287 (+)
FVB/NJ MGP_FVBNJ_G0028776
 protein coding gene Chr4:134555764-134561791 (+)
LP/J MGP_LPJ_G0028908
 protein coding gene Chr4:141280847-141286546 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028802
 protein coding gene Chr4:154391419-154399568 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029460
 protein coding gene Chr4:139543276-139551316 (+)
PWK/PhJ MGP_PWKPhJ_G0027848
 protein coding gene Chr4:132387070-132393816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027673
 protein coding gene Chr4:135301747-135307561 (+)
WSB/EiJ MGP_WSBEiJ_G0028205
 protein coding gene Chr4:139767111-139775671 (+)



Homology
more
  • Human Ortholog
    CAMK2N1, calcium/calmodulin dependent protein kinase II inhibitor 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAMK2N1, calcium/calmodulin dependent protein kinase II inhibitor 1
  • Synonyms
    PRO1489
  • Links
    NCBI Gene ID: 55450
    neXtProt AC: NX_Q7Z7J9
    UniProt: Q7Z7J9

  • Chr Location
    1p36.12; chr1:20482391-20486210 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CAMK2N1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show exacerbated cardiac dysfunction, larger fibrosis area, higher incidence of premature ventricular contractions and higher susceptibility to ventricular tachycardia or ventricular fibrillation after myocardial infarction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    40
  • cDNA Data
    39
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66259 NCBI Gene Model | MGI Sequence Detail 4979 C57BL/6J ±  kb
    transcript NM_025451 RefSeq | MGI Sequence Detail 3613 Not Specified  
    polypeptide Q6QWF9 UniProt | EBI | MGI Sequence Detail 78 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004991 calcium/calmodulin-dependent protein kinase II inhibitor 1
      (term hierarchy)
    • InterPro Domains
      IPR026779 Calcium/calmodulin-dependent protein kinase II inhibitor
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 40
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140380, MGI:2140403
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313857 Wei Z, et al., Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. Free Radic Biol Med. 2021 May 1;167:243-257
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory