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Retreg1 Gene Detail
Summary
  • Symbol
    Retreg1
  • Name
    reticulophagy regulator 1
  • Synonyms
    1810015C04Rik, Fam134b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913520
    NCBI Gene: 66270
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25843266-25973773 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 9.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913520
 protein coding gene Chr15:25840795-25973782 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021751
 protein coding gene Chr15:23851477-23989931 (+)
A/J MGP_AJ_G0021711
 protein coding gene Chr15:22950967-23081041 (+)
AKR/J MGP_AKRJ_G0021689
 protein coding gene Chr15:23454219-23593850 (+)
BALB/cJ MGP_BALBcJ_G0021718
 protein coding gene Chr15:22932641-23064513 (+)
C3H/HeJ MGP_C3HHeJ_G0021494
 protein coding gene Chr15:23501194-23633160 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022157
 protein coding gene Chr15:24877518-25018961 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019697
 protein coding gene Chr15:21264680-21394923 (+)
CAST/EiJ MGP_CASTEiJ_G0021010
 protein coding gene Chr15:23862670-24002505 (+)
CBA/J MGP_CBAJ_G0021463
 protein coding gene Chr15:25688374-25822286 (+)
DBA/2J MGP_DBA2J_G0021587
 protein coding gene Chr15:22720198-22851751 (+)
FVB/NJ MGP_FVBNJ_G0021565
 protein coding gene Chr15:22280410-22413948 (+)
LP/J MGP_LPJ_G0021655
 protein coding gene Chr15:23713947-23849468 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021590
 protein coding gene Chr15:28378094-28512491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022180
 protein coding gene Chr15:23650315-23785857 (+)
PWK/PhJ MGP_PWKPhJ_G0020753
 protein coding gene Chr15:22860822-22997527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020591
 protein coding gene Chr15:23464494-23607928 (+)
WSB/EiJ MGP_WSBEiJ_G0021066
 protein coding gene Chr15:23655138-23790643 (+)



Homology
more
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RETREG1, reticulophagy regulator 1
  • Synonyms
    FAM134B, JK-1, JK1
  • Links
    NCBI Gene ID: 54463
    neXtProt AC: NX_Q9H6L5
    UniProt: Q9H6L5

  • Chr Location
    5p15.1; chr5:16473038-16617101 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RETREG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased thermal nociceptive threshold and sensory neuron degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    104
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022270 Ensembl Gene Model | MGI Sequence Detail 130508 C57BL/6J ±  kb
transcript ENSMUST00000022881 Ensembl | MGI Sequence Detail 3248 Not Applicable  
polypeptide ENSMUSP00000022881 Ensembl | MGI Sequence Detail 480 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146123, MGI:5897461
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:354136 Iavarone F, et al., Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. EMBO Rep. 2024 Jul 22;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory