Tmem218 MGI Mouse Gene Detail - MGI:1913529

Symbol

Tmem218
Name

transmembrane protein 218
Synonyms

1810021J13Rik

Feature Type

protein coding gene
IDs

MGI:1913529
NCBI Gene: 66279
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:37119519-37134524 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 20.74 cM
Mapping Data

2 experiments

SNPs within 2kb

621 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913529	protein coding gene	Chr9:37119519-37135996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034559	protein coding gene	Chr9:35167260-35185362 (+)
A/J	MGP_AJ_G0034538	protein coding gene	Chr9:34244764-34261858 (+)
AKR/J	MGP_AKRJ_G0034465	protein coding gene	Chr9:35003562-35025233 (+)
BALB/cJ	MGP_BALBcJ_G0034529	protein coding gene	Chr9:34082337-34098245 (+)
C3H/HeJ	MGP_C3HHeJ_G0034242	protein coding gene	Chr9:35441866-35458425 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035051	protein coding gene	Chr9:36306222-36321112 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031977	protein coding gene	Chr9:33364090-33379635 (+)
CAST/EiJ	MGP_CASTEiJ_G0033563	protein coding gene	Chr9:35127203-35142997 (+)
CBA/J	MGP_CBAJ_G0034215	protein coding gene	Chr9:37570976-37587622 (+)
DBA/2J	MGP_DBA2J_G0034373	protein coding gene	Chr9:34300835-34317019 (+)
FVB/NJ	MGP_FVBNJ_G0034314	protein coding gene	Chr9:33551788-33568095 (+)
LP/J	MGP_LPJ_G0034458	protein coding gene	Chr9:35390096-35405990 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034360	protein coding gene	Chr9:39170775-39188339 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035070	protein coding gene	Chr9:34942050-34959544 (+)
PWK/PhJ	MGP_PWKPhJ_G0033269	protein coding gene	Chr9:34194997-34210859 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033103	protein coding gene	Chr9:35146050-35161742 (+)
WSB/EiJ	MGP_WSBEiJ_G0033679	protein coding gene	Chr9:34741396-34757310 (+)

Human Ortholog

TMEM218, transmembrane protein 218

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM218, transmembrane protein 218
Synonyms

JBTS39
Links

HGNC:27344

NCBI Gene ID: 219854

neXtProt AC: NX_A2RU14

UniProt: A2RU14
Chr Location

11q24.2; chr11:125094389-125111763 (-) GRCh38

MGI Vertebrate Homology

Tmem218 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM218
Gene Tree

Tmem218

Diseases

1 with Tmem218 mouse models; 1 with human TMEM218 associations

Human Disease

Mouse Models

Senior-Loken syndrome

IDs

View 1 model

Joubert syndrome

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Gene trapped

4
Targeted

3
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show progressive cystic kidney disease and retinal degeneration.

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All GO Annotations

2
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

4
cDNA Data

30
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem218

ZFIN tmem218

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS22975.1

Ensembl

ENSMUSG00000032121 (Evidence)
NCBI Gene

66279

			Length	Strain/Species	Flank
genomic	66279	NCBI Gene Model \| MGI Sequence Detail	15006	C57BL/6J	± kb
transcript	NM_025464	RefSeq \| MGI Sequence Detail	1167	C57BL/6
polypeptide	Q9CQ44	UniProt \| EBI \| MGI Sequence Detail	115	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031151 transmembrane protein 218

(term hierarchy)
InterPro Domains

IPR026771 Transmembrane protein 218

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All nucleic 31

cDNA 30

Primer pair 1

Microarray probesets 4

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MGI:2143246

Summaries

All 29

Developmental Gene Expression 1

Diseases 1

Gene Ontology 1

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931

TSS for Tmem218:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84374	Chr9:37119472-37119491 (+)	-37 bp
Tssr84375	Chr9:37119587-37119656 (+)	103 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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