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Tmem218 Gene Detail
Summary
  • Symbol
    Tmem218
  • Name
    transmembrane protein 218
  • Synonyms
    1810021J13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913529
    NCBI Gene: 66279
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37119519-37134524 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913529
 protein coding gene Chr9:37119519-37135996 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034559
 protein coding gene Chr9:35167260-35185362 (+)
A/J MGP_AJ_G0034538
 protein coding gene Chr9:34244764-34261858 (+)
AKR/J MGP_AKRJ_G0034465
 protein coding gene Chr9:35003562-35025233 (+)
BALB/cJ MGP_BALBcJ_G0034529
 protein coding gene Chr9:34082337-34098245 (+)
C3H/HeJ MGP_C3HHeJ_G0034242
 protein coding gene Chr9:35441866-35458425 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035051
 protein coding gene Chr9:36306222-36321112 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031977
 protein coding gene Chr9:33364090-33379635 (+)
CAST/EiJ MGP_CASTEiJ_G0033563
 protein coding gene Chr9:35127203-35142997 (+)
CBA/J MGP_CBAJ_G0034215
 protein coding gene Chr9:37570976-37587622 (+)
DBA/2J MGP_DBA2J_G0034373
 protein coding gene Chr9:34300835-34317019 (+)
FVB/NJ MGP_FVBNJ_G0034314
 protein coding gene Chr9:33551788-33568095 (+)
LP/J MGP_LPJ_G0034458
 protein coding gene Chr9:35390096-35405990 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034360
 protein coding gene Chr9:39170775-39188339 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035070
 protein coding gene Chr9:34942050-34959544 (+)
PWK/PhJ MGP_PWKPhJ_G0033269
 protein coding gene Chr9:34194997-34210859 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033103
 protein coding gene Chr9:35146050-35161742 (+)
WSB/EiJ MGP_WSBEiJ_G0033679
 protein coding gene Chr9:34741396-34757310 (+)



Homology
more
  • Human Ortholog
    TMEM218, transmembrane protein 218
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM218, transmembrane protein 218
  • Synonyms
    JBTS39
  • Links
    NCBI Gene ID: 219854
    neXtProt AC: NX_A2RU14
    UniProt: A2RU14

  • Chr Location
    11q24.2; chr11:125094389-125111763 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tmem218 mouse models; 1 with human TMEM218 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show progressive cystic kidney disease and retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    4
  • cDNA Data
    30
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66279 NCBI Gene Model | MGI Sequence Detail 15006 C57BL/6J ±  kb
    transcript NM_025464 RefSeq | MGI Sequence Detail 1167 C57BL/6  
    polypeptide Q9CQ44 UniProt | EBI | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143246
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 1
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:282558 Collin GB, et al., Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. Cells. 2020 Apr 10;9(4):931
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory