Mrps21 MGI Mouse Gene Detail - MGI:1913542 - mitochondrial ribosomal protein S21

Symbol

Mrps21
Name

mitochondrial ribosomal protein S21
Synonyms

1810031B19Rik

Feature Type

protein coding gene
IDs

MGI:1913542
NCBI Gene: 66292
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:95769946-95778826 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.36 cM, cytoband F2
Mapping Data

1 experiment

SNPs within 2kb

315 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913542	protein coding gene	Chr3:95769946-95778831 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027596	protein coding gene	Chr3:96643956-96652430 (-)
A/J	MGP_AJ_G0027555	protein coding gene	Chr3:93616403-93625288 (-)
AKR/J	MGP_AKRJ_G0027522	protein coding gene	Chr3:95799724-95808198 (-)
BALB/cJ	MGP_BALBcJ_G0027567	protein coding gene	Chr3:93396511-93405337 (-)
C3H/HeJ	MGP_C3HHeJ_G0027300	protein coding gene	Chr3:96099436-96108313 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028015	protein coding gene	Chr3:100187740-100196214 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025355	protein coding gene	Chr3:89942858-89951859 (-)
CAST/EiJ	MGP_CASTEiJ_G0026750	protein coding gene	Chr3:95376380-95385052 (-)
CBA/J	MGP_CBAJ_G0027277	protein coding gene	Chr3:103855544-103864016 (-)
DBA/2J	MGP_DBA2J_G0027416	protein coding gene	Chr3:92905453-92914330 (-)
FVB/NJ	MGP_FVBNJ_G0027387	protein coding gene	Chr3:90985776-90994259 (-)
LP/J	MGP_LPJ_G0027525	protein coding gene	Chr3:97955716-97964262 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027414	protein coding gene	Chr3:109985414-109994187 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028069	protein coding gene	Chr3:95446220-95455059 (-)
PWK/PhJ	MGP_PWKPhJ_G0026478	protein coding gene	Chr3:92803379-92812553 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026299	protein coding gene	Chr3:93735931-93744711 (-)
WSB/EiJ	MGP_WSBEiJ_G0026832	protein coding gene	Chr3:95837009-95845972 (-)

Human Ortholog

MRPS21, mitochondrial ribosomal protein S21

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPS21, mitochondrial ribosomal protein S21
Synonyms

bS21m, MDS016, MRP-S21, RPMS21
Links

HGNC:14046

NCBI Gene ID: 54460

neXtProt AC: NX_P82921

UniProt: P82921
Chr Location

1q21.2; chr1:150293861-150308979 (+) GRCh38

MGI Vertebrate Homology

Mrps21 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPS21
Gene Tree

Mrps21

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Chemically induced (other)

1
Gene trapped

42
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Mrps21
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available

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All GO Annotations

9
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

13
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrps21

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS38550.1

Ensembl

ENSMUSG00000054312 (Evidence)
NCBI Gene

66292

			Length	Strain/Species	Flank
genomic	66292	NCBI Gene Model \| MGI Sequence Detail	8881	C57BL/6J	± kb
transcript	NM_078479	RefSeq \| MGI Sequence Detail	510	C57BL/6
polypeptide	P58059	UniProt \| EBI \| MGI Sequence Detail	87	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010629 small ribosomal subunit protein bS21m

(term hierarchy)
PDB

7PNT, 7PNU, 7PNV, 7PNW
InterPro Domains

IPR001911 Small ribosomal subunit protein bS21

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrps21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34552	Chr3:95778782-95778823 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24