Senp7 MGI Mouse Gene Detail - MGI:1913565 - SUMO1/sentrin specific peptidase 7

Symbol

Senp7
Name

SUMO1/sentrin specific peptidase 7
Synonyms

2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, mKIAA1707

Feature Type

protein coding gene
IDs

MGI:1913565
NCBI Gene: 66315
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr16:55869306-56010394 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 33.82 cM, cytoband C1.1
Mapping Data

3 experiments

SNPs within 2kb

3973 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913565	protein coding gene	Chr16:55868701-56010394 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022887	protein coding gene	Chr16:55180820-55299350 (+)
A/J	MGP_AJ_G0022854	protein coding gene	Chr16:52807600-52924000 (+)
AKR/J	MGP_AKRJ_G0022826	protein coding gene	Chr16:54475815-54593621 (+)
BALB/cJ	MGP_BALBcJ_G0022854	protein coding gene	Chr16:52911844-53025511 (+)
C3H/HeJ	MGP_C3HHeJ_G0022617	protein coding gene	Chr16:54640000-54784800 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023302	protein coding gene	Chr16:56728207-56860560 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020813	protein coding gene	Chr16:52514743-52629685 (+)
CAST/EiJ	MGP_CASTEiJ_G0022144	protein coding gene	Chr16:55054742-55175577 (+)
CBA/J	MGP_CBAJ_G0022590	protein coding gene	Chr16:58962236-59131456 (+)
DBA/2J	MGP_DBA2J_G0022722	protein coding gene	Chr16:52536701-52689306 (+)
FVB/NJ	MGP_FVBNJ_G0022697	protein coding gene	Chr16:52329842-52447739 (+)
LP/J	MGP_LPJ_G0022789	protein coding gene	Chr16:54981836-55105996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022715	protein coding gene	Chr16:59315067-59449307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023317	protein coding gene	Chr16:54608998-54763527 (+)
PWK/PhJ	MGP_PWKPhJ_G0021883	protein coding gene	Chr16:52894260-53010175 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021713	protein coding gene	Chr16:54421307-54543273 (+)
WSB/EiJ	MGP_WSBEiJ_G0022188	protein coding gene	Chr16:54645352-54785348 (+)

Human Ortholog

SENP7, SUMO specific peptidase 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SENP7, SUMO specific peptidase 7
Links

HGNC:30402

NCBI Gene ID: 57337

neXtProt AC: NX_Q9BQF6

UniProt: Q9BQF6
Chr Location

3q12.3; chr3:101324205-101513241 (-) GRCh38

MGI Vertebrate Homology

Senp7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SENP7
Gene Tree

Senp7

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

70 strains or lines available

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

7
cDNA Data

20
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase senp7

ZFIN senp7b

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All Sequences

110
RefSeq

33
UniProt

7
CCDS

CCDS28221.1, CCDS28222.1, CCDS28223.1, CCDS84243.1, CCDS88943.1

Ensembl

ENSMUSG00000052917 (Evidence)
NCBI Gene

66315

			Length	Strain/Species	Flank
genomic	66315	NCBI Gene Model \| MGI Sequence Detail	141089	C57BL/6J	± kb
transcript	NM_025483	RefSeq \| MGI Sequence Detail	4908	C57BL/6
polypeptide	Q8BUH8	UniProt \| EBI \| MGI Sequence Detail	1037	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014640 sentrin-specific protease 7

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR051947 Sentrin-specific protease

IPR003653 Ulp1 protease family, C-terminal catalytic domain
GlyGen

Q8BUH8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 20

Microarray probesets 6

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MGI:1920119, MGI:1924062, MGI:1924964, MGI:2146486

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:357981 Pei J, et al., Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. J Biol Chem. 2024 Apr 25;300(6):107319

TSS for Senp7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138804	Chr16:55895762-55895855 (+)	26,503 bp
Tssr138805	Chr16:55895871-55895881 (+)	26,570 bp
Tssr138806	Chr16:55947735-55947758 (+)	78,441 bp
Tssr138807	Chr16:55947766-55947802 (+)	78,478 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24