Atp6v1c1 MGI Mouse Gene Detail - MGI:1913585 - ATPase, H+ transporting, lysosomal V1 subunit C1

Symbol

Atp6v1c1
Name

ATPase, H+ transporting, lysosomal V1 subunit C1
Synonyms

1700025B18Rik

Feature Type

protein coding gene
IDs

MGI:1913585
NCBI Gene: 66335
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:38662177-38692690 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.18 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

686 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913585	protein coding gene	Chr15:38662096-38692690 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021809	protein coding gene	Chr15:37199697-37231730 (+)
A/J	MGP_AJ_G0021769	protein coding gene	Chr15:35748230-35779755 (+)
AKR/J	MGP_AKRJ_G0021750	protein coding gene	Chr15:36823597-36856205 (+)
BALB/cJ	MGP_BALBcJ_G0021776	protein coding gene	Chr15:35797244-35827682 (+)
C3H/HeJ	MGP_C3HHeJ_G0021550	protein coding gene	Chr15:36758718-36790156 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022215	protein coding gene	Chr15:38629338-38661807 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019752	protein coding gene	Chr15:33524959-33556016 (+)
CAST/EiJ	MGP_CASTEiJ_G0021067	protein coding gene	Chr15:37187931-37218281 (+)
CBA/J	MGP_CBAJ_G0021519	protein coding gene	Chr15:39865860-39900559 (+)
DBA/2J	MGP_DBA2J_G0021643	protein coding gene	Chr15:35589921-35620997 (+)
FVB/NJ	MGP_FVBNJ_G0021621	protein coding gene	Chr15:35001151-35031640 (+)
LP/J	MGP_LPJ_G0021713	protein coding gene	Chr15:37061610-37095552 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0022238	protein coding gene	Chr15:36957701-36989292 (+)
PWK/PhJ	MGP_PWKPhJ_G0020812	protein coding gene	Chr15:35651317-35683539 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020649	protein coding gene	Chr15:36653746-36683826 (+)
WSB/EiJ	MGP_WSBEiJ_G0021122	protein coding gene	Chr15:36905410-36937062 (+)

Human Ortholog

ATP6V1C1, ATPase H+ transporting V1 subunit C1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP6V1C1, ATPase H+ transporting V1 subunit C1
Synonyms

ATP6C, ATP6D, VATC, Vma5
Links

HGNC:856

NCBI Gene ID: 528

neXtProt AC: NX_P21283

UniProt: P21283
Chr Location

8q22.3; chr8:103021063-103073051 (+) GRCh38

MGI Vertebrate Homology

Atp6v1c1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ATP6V1C1
Gene Tree

Atp6v1c1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

11
Targeted

3
Genomic Mutations

2 involving Atp6v1c1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

127
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp6v1c1

ZFIN atp6v1c1a, atp6v1c1b

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All Sequences

56
RefSeq

4
UniProt

5
CCDS

CCDS27439.1

Ensembl

ENSMUSG00000022295 (Evidence)
NCBI Gene

66335

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022295	Ensembl Gene Model \| MGI Sequence Detail	30514	C57BL/6J	± kb
transcript	ENSMUST00000022904	Ensembl \| MGI Sequence Detail	2071	Not Applicable
polypeptide	ENSMUSP00000022904	Ensembl \| MGI Sequence Detail	382	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004483 V-type proton ATPase subunit C 1

(term hierarchy)
PDB

9BRA, 9BRQ, 9BRR, 9BRS, 9BRT, 9BRU
InterPro Domains

IPR004907 ATPase, V1 complex, subunit C

IPR036132 Vacuolar ATP synthase subunit C superfamily
GlyGen

Q9Z1G3 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 14

Primer pair 1

Microarray probesets 6

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MGI:2146327

Summaries

All 48

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Atp6v1c1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131123	Chr15:38662149-38662156 (+)	-24 bp
Tssr131124	Chr15:38662158-38662225 (+)	15 bp
Tssr131125	Chr15:38662229-38662243 (+)	59 bp
Tssr131126	Chr15:38674136-38674175 (+)	11,979 bp
Tssr131127	Chr15:38686708-38686713 (+)	24,534 bp
Tssr131128	Chr15:38691860-38691884 (+)	29,695 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24