Ttll9 MGI Mouse Gene Detail - MGI:1913589 - tubulin tyrosine ligase-like family, member 9

Symbol

Ttll9
Name

tubulin tyrosine ligase-like family, member 9
Synonyms

1700016F23Rik, 4930509O20Rik

Feature Type

protein coding gene
IDs

MGI:1913589
NCBI Gene: 74711
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:152804405-152850402 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM, cytoband H2
Mapping Data

4 experiments

SNPs within 2kb

1575 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913589	protein coding gene	Chr2:152792966-152850402 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026683	protein coding gene	Chr2:157565373-157617052 (+)
A/J	MGP_AJ_G0026649	protein coding gene	Chr2:151261828-151310267 (+)
AKR/J	MGP_AKRJ_G0026619	protein coding gene	Chr2:155685320-155733445 (+)
BALB/cJ	MGP_BALBcJ_G0026658	protein coding gene	Chr2:151572189-151620202 (+)
C3H/HeJ	MGP_C3HHeJ_G0026401	protein coding gene	Chr2:156053711-156102652 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027107	protein coding gene	Chr2:162139353-162189507 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024478	protein coding gene	Chr2:144853322-144898857 (+)
CAST/EiJ	MGP_CASTEiJ_G0025862	protein coding gene	Chr2:156315030-156364719 (+)
CBA/J	MGP_CBAJ_G0026379	protein coding gene	Chr2:168103530-168154450 (+)
DBA/2J	MGP_DBA2J_G0026515	protein coding gene	Chr2:150471382-150516956 (+)
FVB/NJ	MGP_FVBNJ_G0026481	protein coding gene	Chr2:148938803-148984866 (+)
LP/J	MGP_LPJ_G0026619	protein coding gene	Chr2:157714567-157764796 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026502	protein coding gene	Chr2:172165899-172221133 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027163	protein coding gene	Chr2:155578616-155629112 (+)
PWK/PhJ	MGP_PWKPhJ_G0025596	protein coding gene	Chr2:150001795-150053460 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025399	protein coding gene	Chr2:154411965-154462403 (+)
WSB/EiJ	MGP_WSBEiJ_G0025932	protein coding gene	Chr2:156483070-156531075 (+)

Human Ortholog

TTLL9, tubulin tyrosine ligase like 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TTLL9, tubulin tyrosine ligase like 9
Synonyms

C20orf125
Links

HGNC:16118

NCBI Gene ID: 164395

neXtProt AC: NX_Q3SXZ7

UniProt: Q3SXZ7
Chr Location

20q11.21; chr20:31870634-31945000 (+) GRCh38

MGI Vertebrate Homology

Ttll9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TTLL9
Gene Tree

Ttll9

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Phenotype Summary

15 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Ttll9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility associated with oligozoospermia, detached sperm flagella, abnormal sperm axonemes with loss of doublet 7 and reduced polyglutamylation of doublet 5, and asthenozoospermia with frequent stalls after anti-hook bending.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

85
RefSeq

32
UniProt

7
CCDS

CCDS16903.1, CCDS38283.1

Ensembl

ENSMUSG00000074673 (Evidence)
NCBI Gene

74711

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074673	Ensembl Gene Model \| MGI Sequence Detail	45998	C57BL/6J	± kb
transcript	ENSMUST00000103155	Ensembl \| MGI Sequence Detail	1552	Not Applicable
polypeptide	ENSMUSP00000099444	Ensembl \| MGI Sequence Detail	464	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000031516 probable tubulin polyglutamylase TTLL9

(term hierarchy)
EC

6.3.2.-
InterPro Domains

IPR013815 ATP-grasp fold, subdomain 1

IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 5

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MGI:1921961, MGI:2146611

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:259707 Ye B, et al., Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261

TSS for Ttll9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20853	Chr2:152804377-152804389 (+)	-22 bp
Tssr20854	Chr2:152804406-152804430 (+)	13 bp
Tssr20855	Chr2:152804441-152804448 (+)	40 bp
Tssr20856	Chr2:152809855-152809872 (+)	5,459 bp
Tssr20857	Chr2:152830549-152830552 (+)	26,146 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24