Ndufb11b Gene Detail

Summary

• Symbol
  Ndufb11b
• Name
  NADH:ubiquinone oxidoreductase subunit B11B
• Synonyms
  1700029P11Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1913596
  NCBI Gene: 66346
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr15:81864741-81865764 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 38.32 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  137 from dbSNP Build 142
• Strain Annotations
  14

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913596	protein coding gene	Chr15:81864741-81865764 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022128	protein coding gene	Chr15:82458267-82461048 (+)
A/J	MGP_AJ_G0022089	protein coding gene	Chr15:79544854-79545889 (+)
AKR/J	MGP_AKRJ_G0022064	protein coding gene	Chr15:81743654-81745506 (+)
BALB/cJ	MGP_BALBcJ_G0035952	protein coding gene	ChrX:98587972-98589004 (+)
C3H/HeJ	MGP_C3HHeJ_G0035658	protein coding gene	ChrX:100312744-100314105 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0020066	protein coding gene	Chr15:75984861-75985893 (+)
CAST/EiJ	MGP_CASTEiJ_G0021385	protein coding gene	Chr15:82551456-82552490 (+)
CBA/J	MGP_CBAJ_G0021830	protein coding gene	Chr15:88366308-88366984 (+)
DBA/2J	no annotation
FVB/NJ	MGP_FVBNJ_G0035728	protein coding gene	ChrX:98351757-98352868 (+)
LP/J	MGP_LPJ_G0035880	protein coding gene	ChrX:100864235-100865304 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0022552	protein coding gene	Chr15:81841805-81844042 (+)
PWK/PhJ	MGP_PWKPhJ_G0023477	protein coding gene	Chr18:64826586-64827610 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027132	protein coding gene	Chr4:91332804-91333827 (-)
WSB/EiJ	no annotation

Homology

• Human Ortholog
  NDUFB11, NADH:ubiquinone oxidoreductase subunit B11

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  NDUFB11, NADH:ubiquinone oxidoreductase subunit B11
  
• Synonyms
  CI-ESSS, ESSS, MC1DN30, Np15, NP17.3, P17.3
• Links
  HGNC:20372

  NCBI Gene ID: 54539

  neXtProt AC: NX_Q9NX14

  UniProt: Q9NX14

  
  
• Chr Location
  Xp11.3

---

• MGI Vertebrate Homology
  Ndufb11b stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: NDUFB11
• Gene Tree
  Ndufb11b
  

Human Diseases

• Diseases
  2 with human NDUFB11 associations

				Human Disease	Mouse Models
				linear skin defects with multiple congenital anomalies 3 IDs linear skin defects with multiple congenital anomalies 3       DOID:0111876 OMIM:300952
				nuclear type mitochondrial complex I deficiency 30 IDs nuclear type mitochondrial complex I deficiency 30       DOID:0112098 OMIM:301021

Click on a disease name to see all genes associated with that disease.

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  21 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  1
• Genomic Mutations
  3 involving Ndufb11b
• Find Mice (IMSR)
  7 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  6
• GO References
  3

Expression

• Assay Results
  771
• Tissues
  12
• cDNA Data
  5
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  29
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS37152.1

• Ensembl
  ENSMUSG00000061633 (Evidence)
• NCBI Gene
  66346

Representative Sequences			Length	Strain/Species
genomic	66346	NCBI Gene Model | MGI Sequence Detail	1024	C57BL/6J
transcript	NM_025503	RefSeq | MGI Sequence Detail	1034	C57BL/6
polypeptide	NP_079779	RefSeq | MGI Sequence Detail	150	C57BL/6

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR019329 NADH:ubiquinone oxidoreductase, ESSS subunit

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:6467241

References

• Summaries
  All 40

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 3

  Phenotypes 21
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Ndufb11b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132321	Chr15:81864710-81864747 (+)	-12 bp