Sln MGI Mouse Gene Detail - MGI:1913652

Symbol

Sln
Name

sarcolipin
Synonyms

2310045A07Rik

Feature Type

protein coding gene
IDs

MGI:1913652
NCBI Gene: 66402
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:53757535-53761133 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 29.24 cM, cytoband C
Mapping Data

2 experiments

SNPs within 2kb

179 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913652	protein coding gene	Chr9:53757448-53761844 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034817	protein coding gene	Chr9:52900856-52904449 (+)
A/J	MGP_AJ_G0034798	protein coding gene	Chr9:51222451-51226044 (+)
AKR/J	MGP_AKRJ_G0034726	protein coding gene	Chr9:52335109-52338702 (+)
BALB/cJ	MGP_BALBcJ_G0034790	protein coding gene	Chr9:50971125-50974718 (+)
C3H/HeJ	MGP_C3HHeJ_G0034500	protein coding gene	Chr9:52820812-52824405 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035309	protein coding gene	Chr9:54382560-54386153 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032222	protein coding gene	Chr9:50618933-50622531 (+)
CAST/EiJ	MGP_CASTEiJ_G0033822	protein coding gene	Chr9:52827865-52831453 (+)
CBA/J	MGP_CBAJ_G0034471	protein coding gene	Chr9:56233200-56236793 (+)
DBA/2J	MGP_DBA2J_G0034630	protein coding gene	Chr9:51090285-51093878 (+)
FVB/NJ	MGP_FVBNJ_G0034572	protein coding gene	Chr9:50281590-50285183 (+)
LP/J	MGP_LPJ_G0034712	protein coding gene	Chr9:53198808-53202401 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034615	protein coding gene	Chr9:57806900-57810493 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035331	protein coding gene	Chr9:52352771-52356364 (+)
PWK/PhJ	MGP_PWKPhJ_G0033526	protein coding gene	Chr9:51074455-51078030 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033362	protein coding gene	Chr9:52616448-52620044 (+)
WSB/EiJ	MGP_WSBEiJ_G0033934	protein coding gene	Chr9:52337877-52341470 (+)

Human Ortholog

SLN, sarcolipin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLN, sarcolipin
Links

HGNC:11089

NCBI Gene ID: 6588

neXtProt AC: NX_O00631

UniProt: O00631
Chr Location

11q22.3; chr11:107707378-107719693 (-) GRCh38

MGI Vertebrate Homology

Sln stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLN
Gene Tree

Sln

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Phenotype Summary

22 phenotypes from 3 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

3
Targeted

7
Transgenic

1
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased cardiac contractility and impaired muscle-based thermogenesis.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

29
cDNA Data

51
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS40640.1

Ensembl

ENSMUSG00000042045 (Evidence)
NCBI Gene

66402

			Length	Strain/Species	Flank
genomic	66402	NCBI Gene Model \| MGI Sequence Detail	3599	C57BL/6J	± kb
transcript	NM_025540	RefSeq \| MGI Sequence Detail	536	C57BL/6
polypeptide	Q9CQD6	UniProt \| EBI \| MGI Sequence Detail	31	Not Applicable

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UniProt

1 Sequence
InterPro Domains

IPR008028 Sarcolipin

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All nucleic 57

cDNA 52

Primer pair 4

Other 1

Microarray probesets 4

Summaries

All 74

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 37
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:348091 Skop V, et al., Beyond day and night: The importance of ultradian rhythms in mouse physiology. Mol Metab. 2024 Apr 23;84:101946

TSS for Sln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85148	Chr9:53757527-53757541 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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