Asf1a MGI Mouse Gene Detail - MGI:1913653 - anti-silencing function 1A histone chaperone

Symbol

Asf1a
Name

anti-silencing function 1A histone chaperone
Synonyms

2310079C17Rik

Feature Type

protein coding gene
IDs

MGI:1913653
NCBI Gene: 66403
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:53473057-53485321 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 27.24 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

343 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913653	protein coding gene	Chr10:53472853-53485321 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017231	protein coding gene	Chr10:52792521-52804773 (+)
A/J	MGP_AJ_G0017207	protein coding gene	Chr10:51227452-51239704 (+)
AKR/J	MGP_AKRJ_G0017167	protein coding gene	Chr10:52233491-52245743 (+)
BALB/cJ	MGP_BALBcJ_G0017168	protein coding gene	Chr10:51367526-51379778 (+)
C3H/HeJ	MGP_C3HHeJ_G0016991	protein coding gene	Chr10:52492842-52505096 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017627	protein coding gene	Chr10:54436682-54448934 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015321	protein coding gene	Chr10:48396635-48409100 (+)
CAST/EiJ	MGP_CASTEiJ_G0016564	protein coding gene	Chr10:52593641-52606105 (+)
CBA/J	MGP_CBAJ_G0016963	protein coding gene	Chr10:56757545-56769797 (+)
DBA/2J	MGP_DBA2J_G0017068	protein coding gene	Chr10:50664840-50677092 (+)
FVB/NJ	MGP_FVBNJ_G0017063	protein coding gene	Chr10:49961771-49974023 (+)
LP/J	MGP_LPJ_G0017143	protein coding gene	Chr10:52855274-52867526 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017092	protein coding gene	Chr10:58707055-58719307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017664	protein coding gene	Chr10:52155228-52167480 (+)
PWK/PhJ	MGP_PWKPhJ_G0016345	protein coding gene	Chr10:50515511-50528164 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016131	protein coding gene	Chr10:51782900-51795489 (+)
WSB/EiJ	MGP_WSBEiJ_G0016629	protein coding gene	Chr10:52396267-52408520 (+)

Human Ortholog

ASF1A, anti-silencing function 1A histone chaperone

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASF1A, anti-silencing function 1A histone chaperone
Synonyms

CGI-98, CIA, HSPC146
Links

HGNC:20995

NCBI Gene ID: 25842

neXtProt AC: NX_Q9Y294

UniProt: Q9Y294
Chr Location

6q22.31; chr6:118894152-118909171 (+) GRCh38

MGI Vertebrate Homology

Asf1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ASF1A
Gene Tree

Asf1a

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
1 images
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

66
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

61
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Asf1a
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele die at midgestation.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

64
cDNA Data

13
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asf1a

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All Sequences

48
RefSeq

2
UniProt

3
CCDS

CCDS23847.1

Ensembl

ENSMUSG00000019857 (Evidence)
NCBI Gene

66403

			Length	Strain/Species	Flank
genomic	66403	NCBI Gene Model \| MGI Sequence Detail	12265	C57BL/6J	± kb
transcript	NM_025541	RefSeq \| MGI Sequence Detail	2192	C57BL/6
polypeptide	Q9CQE6	UniProt \| EBI \| MGI Sequence Detail	204	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004367 histone chaperone ASF1A

(term hierarchy)
InterPro Domains

IPR006818 Histone chaperone ASF1-like

IPR036747 Histone chaperone ASF1-like superfamily

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 5

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MGI:2143923

Summaries

All 58

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 24
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asf1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93332	Chr10:53472007-53472010 (+)	-1,048 bp
Tssr93333	Chr10:53472891-53472904 (+)	-159 bp
Tssr93334	Chr10:53472911-53472922 (+)	-140 bp
Tssr93335	Chr10:53472940-53472949 (+)	-112 bp
Tssr93336	Chr10:53472982-53472994 (+)	-69 bp
Tssr93337	Chr10:53473019-53473030 (+)	-32 bp
Tssr93338	Chr10:53473032-53473100 (+)	9 bp
Tssr93339	Chr10:53473110-53473117 (+)	57 bp
Tssr93340	Chr10:53473156-53473171 (+)	107 bp
Tssr93341	Chr10:53473206-53473215 (+)	154 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24