Anp32e MGI Mouse Gene Detail - MGI:1913721 - acidic nuclear phosphoprotein 32 family member E

Symbol

Anp32e
Name

acidic nuclear phosphoprotein 32 family member E
Synonyms

2810018A15Rik, CPD1, LANP-L, MGC:11640

Feature Type

protein coding gene
IDs

MGI:1913721
NCBI Gene: 66471
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:95836557-95854699 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 41.59 cM
Mapping Data

2 experiments

SNPs within 2kb

440 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913721	protein coding gene	Chr3:95836557-95854702 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027601	protein coding gene	Chr3:96715367-96735163 (+)
A/J	MGP_AJ_G0027560	protein coding gene	Chr3:93685272-93705287 (+)
AKR/J	MGP_AKRJ_G0027527	protein coding gene	Chr3:95878467-95900048 (+)
BALB/cJ	MGP_BALBcJ_G0027572	protein coding gene	Chr3:93463220-93482452 (+)
C3H/HeJ	MGP_C3HHeJ_G0027305	protein coding gene	Chr3:96168520-96189099 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028020	protein coding gene	Chr3:100268270-100289816 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025360	protein coding gene	Chr3:90012124-90028857 (+)
CAST/EiJ	MGP_CASTEiJ_G0026755	protein coding gene	Chr3:95457898-95479830 (+)
CBA/J	MGP_CBAJ_G0027282	protein coding gene	Chr3:103950068-103974307 (+)
DBA/2J	MGP_DBA2J_G0027421	protein coding gene	Chr3:92974508-92992923 (+)
FVB/NJ	MGP_FVBNJ_G0027392	protein coding gene	Chr3:91052107-91072289 (+)
LP/J	MGP_LPJ_G0027530	protein coding gene	Chr3:98031725-98049909 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027419	protein coding gene	Chr3:110060974-110081527 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028074	protein coding gene	Chr3:95519952-95538476 (+)
PWK/PhJ	MGP_PWKPhJ_G0026483	protein coding gene	Chr3:92877048-92895069 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026304	protein coding gene	Chr3:93813247-93832154 (+)
WSB/EiJ	MGP_WSBEiJ_G0026837	protein coding gene	Chr3:95912055-95930903 (+)

Human Ortholog

ANP32E, acidic nuclear phosphoprotein 32 family member E

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANP32E, acidic nuclear phosphoprotein 32 family member E
Synonyms

LANP-L, LANPL
Links

HGNC:16673

NCBI Gene ID: 81611

neXtProt AC: NX_Q9BTT0

UniProt: Q9BTT0
Chr Location

1q21.2; chr1:150218417-150236156 (-) GRCh38

MGI Vertebrate Homology

Anp32e stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANP32E
Gene Tree

Anp32e

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 1 genetic background
7 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

25
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Anp32e
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

Mice homozygous for a gene trapped allele exhibit mild neurological deficits. Mice homozygous for a knock-out allele are phenotypically normal.

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All GO Annotations

21
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

10
cDNA Data

280
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase anp32e

ZFIN anp32e

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All Sequences

91
RefSeq

8
UniProt

7
CCDS

CCDS17626.1, CCDS57238.1, CCDS57239.1

Ensembl

ENSMUSG00000015749 (Evidence)
NCBI Gene

66471

			Length	Strain/Species	Flank
genomic	66471	NCBI Gene Model \| MGI Sequence Detail	18143	C57BL/6J	± kb
transcript	NM_023210	RefSeq \| MGI Sequence Detail	3273	Not Specified
polypeptide	P97822	UniProt \| EBI \| MGI Sequence Detail	260	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000004067 acidic leucine-rich nuclear phosphoprotein 32 family member E

(term hierarchy)
InterPro Domains

IPR045081 Acidic leucine-rich nuclear phosphoprotein 32

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

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All nucleic 281

cDNA 281

Microarray probesets 4

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MGI:2139621, MGI:2139684

Summaries

All 53

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 21
Earliest

J:82796 Radrizzani M, et al., Development of monoclonal oligobodies and chemically synthesized oligobodies. Medicina (B Aires). 2000;60 Suppl 2:55-60
Latest

J:349245 Gopinathan G, et al., CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation. PLoS Biol. 2024 Apr;22(4):e3002574

TSS for Anp32e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30656	Chr3:95836591-95836610 (+)	44 bp
Tssr30657	Chr3:95836644-95836655 (+)	93 bp
Tssr30658	Chr3:95836741-95836744 (+)	186 bp
Tssr30659	Chr3:95841310-95841334 (+)	4,765 bp
Tssr30660	Chr3:95842113-95842148 (+)	5,574 bp
Tssr30661	Chr3:95844455-95844469 (+)	7,905 bp
Tssr30662	Chr3:95845215-95845232 (+)	8,667 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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