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Ppdpf Gene Detail
Summary
  • Symbol
    Ppdpf
  • Name
    pancreatic progenitor cell differentiation and proliferation factor
  • Synonyms
    0610012G23Rik, 2610317A05Rik, 2700038C09Rik, 3110053G12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913746
    NCBI Gene: 66496
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180829040-180830564 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.62 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913746
 protein coding gene Chr2:180828615-180830564 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027012
 protein coding gene Chr2:187762557-187764081 (+)
A/J MGP_AJ_G0026978
 protein coding gene Chr2:180037625-180039149 (+)
AKR/J MGP_AKRJ_G0026948
 protein coding gene Chr2:185431627-185433151 (+)
BALB/cJ MGP_BALBcJ_G0026987
 protein coding gene Chr2:180503479-180505003 (+)
C3H/HeJ MGP_C3HHeJ_G0026728
 protein coding gene Chr2:185788161-185789685 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027433
 protein coding gene Chr2:193182663-193184659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024798
 protein coding gene Chr2:170725416-170726942 (+)
CAST/EiJ MGP_CASTEiJ_G0026187
 protein coding gene Chr2:184045368-184046892 (+)
CBA/J MGP_CBAJ_G0026705
 protein coding gene Chr2:200184884-200186408 (+)
DBA/2J MGP_DBA2J_G0026843
 protein coding gene Chr2:179130874-179132398 (+)
FVB/NJ MGP_FVBNJ_G0026809
 protein coding gene Chr2:177747806-177749330 (+)
LP/J MGP_LPJ_G0026944
 protein coding gene Chr2:187774284-187775808 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026828
 protein coding gene Chr2:202753683-202755207 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027492
 protein coding gene Chr2:185400612-185402136 (+)
PWK/PhJ MGP_PWKPhJ_G0025923
 protein coding gene Chr2:176656229-176657753 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025723
 protein coding gene Chr2:181888281-181892078 (+)
WSB/EiJ MGP_WSBEiJ_G0026259
 protein coding gene Chr2:186386624-186388148 (+)



Homology
more
  • Human Ortholog
    PPDPF, pancreatic progenitor cell differentiation and proliferation factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPDPF, pancreatic progenitor cell differentiation and proliferation factor
  • Synonyms
    C20orf149, dJ697K14.9, exdpf
  • Links
    NCBI Gene ID: 79144
    neXtProt AC: NX_Q9H3Y8
    UniProt: Q9H3Y8

  • Chr Location
    20q13.33; chr20:63520741-63522206 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ppdpf mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Liver-specific knock-out mice develop fatty liver disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    719
  • Tissues
    8
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016344 Ensembl Gene Model | MGI Sequence Detail 1525 C57BL/6J ±  kb
    transcript ENSMUST00000016488 Ensembl | MGI Sequence Detail 1160 Not Applicable  
    polypeptide ENSMUSP00000016488 Ensembl | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000007244 exocrine differentiation and proliferation factor
      (term hierarchy)
    • InterPro Domains
      IPR026754 Pancreatic progenitor cell differentiation and proliferation factor
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1913313, MGI:1919783, MGI:1920465
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 2
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory