Slc30a7 MGI Mouse Gene Detail - MGI:1913750 - solute carrier family 30 (zinc transporter), member 7

Symbol

Slc30a7
Name

solute carrier family 30 (zinc transporter), member 7
Synonyms

1810059J10Rik, 2610034N15Rik, 4833428C12Rik, ZnT-7, ZnT7

Feature Type

protein coding gene
IDs

MGI:1913750
NCBI Gene: 66500
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:115732622-115801055 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 50.16 cM, cytoband G2
Mapping Data

4 experiments

SNPs within 2kb

2046 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913750	protein coding gene	Chr3:115732622-115801079 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027805	protein coding gene	Chr3:117807060-117880578 (-)
A/J	MGP_AJ_G0027763	protein coding gene	Chr3:113949167-114020035 (-)
AKR/J	MGP_AKRJ_G0027729	protein coding gene	Chr3:116818857-116888138 (-)
BALB/cJ	MGP_BALBcJ_G0027775	protein coding gene	Chr3:113801760-113869711 (-)
C3H/HeJ	MGP_C3HHeJ_G0027506	protein coding gene	Chr3:117194818-117265409 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028221	protein coding gene	Chr3:122141736-122212873 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025560	protein coding gene	Chr3:109648054-109713276 (-)
CAST/EiJ	MGP_CASTEiJ_G0026962	protein coding gene	Chr3:116465846-116535579 (-)
CBA/J	MGP_CBAJ_G0027481	protein coding gene	Chr3:126301035-126374999 (-)
DBA/2J	MGP_DBA2J_G0027622	protein coding gene	Chr3:113187965-113263682 (-)
FVB/NJ	MGP_FVBNJ_G0027590	protein coding gene	Chr3:110834229-110902126 (-)
LP/J	MGP_LPJ_G0027732	protein coding gene	Chr3:119347382-119420427 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027620	protein coding gene	Chr3:133682888-133753056 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028277	protein coding gene	Chr3:116375560-116450866 (-)
PWK/PhJ	MGP_PWKPhJ_G0026688	protein coding gene	Chr3:112825655-112895396 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026510	protein coding gene	Chr3:114387482-114457133 (-)
WSB/EiJ	MGP_WSBEiJ_G0027042	protein coding gene	Chr3:117052746-117124363 (-)

Human Ortholog

SLC30A7, solute carrier family 30 member 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC30A7, solute carrier family 30 member 7
Synonyms

ZHS, ZnT-7, ZNT7, ZnTL2
Links

HGNC:19306

NCBI Gene ID: 148867

neXtProt AC: NX_Q8NEW0

UniProt: Q8NEW0
Chr Location

1p21.2; chr1:100896076-100996078 (+) GRCh38

MGI Vertebrate Homology

Slc30a7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC30A7
Gene Tree

Slc30a7

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References

1 with disease annotations

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Slc30a7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit a low body zinc status, reduced food intake and poor body weight gain, and are lean due to a significant reduction in body fat accumulation; however, no signs of hair growth abnormalities or dermatitis are observed.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

49
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc30a7

ZFIN slc30a7

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All Sequences

50
RefSeq

6
UniProt

1
CCDS

CCDS17783.1

Ensembl

ENSMUSG00000054414 (Evidence)
NCBI Gene

66500

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054414	Ensembl Gene Model \| MGI Sequence Detail	68434	C57BL/6J	± kb
transcript	ENSMUST00000067485	Ensembl \| MGI Sequence Detail	9020	Not Applicable
polypeptide	ENSMUSP00000065254	Ensembl \| MGI Sequence Detail	378	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015080 zinc transporter 7

(term hierarchy)
InterPro Domains

IPR002524 Cation efflux protein

IPR027469 Cation efflux transmembrane domain superfamily

IPR045316 Zinc transporter Msc2-like

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 5

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MGI:1917163, MGI:2139735, MGI:3026979

Summaries

All 53

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc30a7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35295	Chr3:115801048-115801060 (-)	1 bp
Tssr35294	Chr3:115800989-115801045 (-)	38 bp
Tssr35293	Chr3:115800096-115800100 (-)	957 bp
Tssr35292	Chr3:115782959-115782988 (-)	18,081 bp
Tssr35291	Chr3:115767980-115767985 (-)	33,072 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24