Rps19bp1 MGI Mouse Gene Detail - MGI:1913788 - ribosomal protein S19 binding protein 1

Symbol

Rps19bp1
Name

ribosomal protein S19 binding protein 1
Synonyms

2510038A11Rik, S19BP

Feature Type

protein coding gene
IDs

MGI:1913788
NCBI Gene: 66538
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:80144815-80148507 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM
Mapping Data

2 experiments

SNPs within 2kb

210 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913788	protein coding gene	Chr15:80144815-80148516 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022098	protein coding gene	Chr15:80596279-80599951 (-)
A/J	MGP_AJ_G0022059	protein coding gene	Chr15:77792816-77796488 (-)
AKR/J	MGP_AKRJ_G0022034	protein coding gene	Chr15:79968746-79972418 (-)
BALB/cJ	MGP_BALBcJ_G0022065	protein coding gene	Chr15:77799803-77803475 (-)
C3H/HeJ	MGP_C3HHeJ_G0021836	protein coding gene	Chr15:79961427-79965099 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022508	protein coding gene	Chr15:83771308-83775000 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020038	protein coding gene	Chr15:74281688-74285680 (-)
CAST/EiJ	MGP_CASTEiJ_G0021357	protein coding gene	Chr15:80676013-80679710 (-)
CBA/J	MGP_CBAJ_G0021801	protein coding gene	Chr15:86410302-86413974 (-)
DBA/2J	MGP_DBA2J_G0021930	protein coding gene	Chr15:77283039-77286711 (-)
FVB/NJ	MGP_FVBNJ_G0021908	protein coding gene	Chr15:76306909-76310581 (-)
LP/J	MGP_LPJ_G0021998	protein coding gene	Chr15:80768260-80771932 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021928	protein coding gene	Chr15:91429961-91433633 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022522	protein coding gene	Chr15:80003954-80007626 (-)
PWK/PhJ	MGP_PWKPhJ_G0021099	protein coding gene	Chr15:77298563-77302318 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020936	protein coding gene	Chr15:79808992-79812661 (-)
WSB/EiJ	MGP_WSBEiJ_G0021409	protein coding gene	Chr15:80407920-80411592 (-)

Human Ortholog

RPS19BP1, ribosomal protein S19 binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS19BP1, ribosomal protein S19 binding protein 1
Synonyms

AROS, S19BP
Links

HGNC:28749

NCBI Gene ID: 91582

neXtProt AC: NX_Q86WX3

UniProt: Q86WX3
Chr Location

22q13.1; chr22:39529093-39532761 (-) GRCh38

MGI Vertebrate Homology

Rps19bp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS19BP1
Gene Tree

Rps19bp1

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Rps19bp1
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

10
cDNA Data

43
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps19bp1

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS27662.1

Ensembl

ENSMUSG00000051518 (Evidence)
NCBI Gene

66538

			Length	Strain/Species	Flank
genomic	66538	NCBI Gene Model \| MGI Sequence Detail	3693	C57BL/6J	± kb
transcript	NM_175109	RefSeq \| MGI Sequence Detail	830	C57BL/6
polypeptide	Q8C6B9	UniProt \| EBI \| MGI Sequence Detail	143	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014262 active regulator of SIRT1

(term hierarchy)
InterPro Domains

IPR023262 Active regulator of SIRT1
GlyGen

Q8C6B9 1 site, 1 O-linked glycan (1 site)

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All nucleic 43

cDNA 43

Microarray probesets 3

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MGI:2146044

Summaries

All 59

Developmental Gene Expression 1

Diseases 1

Gene Ontology 5

Phenotypes 33
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rps19bp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135435	Chr15:80148477-80148523 (-)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24