Xpo5 MGI Mouse Gene Detail - MGI:1913789

Symbol

Xpo5
Name

exportin 5
Synonyms

2410004H11Rik, 2700038C24Rik, Exp5

Feature Type

protein coding gene
IDs

MGI:1913789
NCBI Gene: 72322
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:46513737-46554524 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.90 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

1030 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913789	protein coding gene	Chr17:46513708-46554524 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023806	protein coding gene	Chr17:47250263-47288739 (+)
A/J	MGP_AJ_G0023764	protein coding gene	Chr17:46112731-46152225 (+)
AKR/J	MGP_AKRJ_G0023735	protein coding gene	Chr17:46447974-46487206 (+)
BALB/cJ	MGP_BALBcJ_G0023768	protein coding gene	Chr17:46015311-46054412 (+)
C3H/HeJ	MGP_C3HHeJ_G0023532	protein coding gene	Chr17:47178564-47218248 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024211	protein coding gene	Chr17:49295629-49336316 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021661	protein coding gene	Chr17:42914926-42954948 (+)
CAST/EiJ	MGP_CASTEiJ_G0023013	protein coding gene	Chr17:47302958-47342337 (+)
CBA/J	MGP_CBAJ_G0023508	protein coding gene	Chr17:51058946-51099853 (+)
DBA/2J	MGP_DBA2J_G0023634	protein coding gene	Chr17:44902132-44941768 (+)
FVB/NJ	MGP_FVBNJ_G0023601	protein coding gene	Chr17:44506487-44546090 (+)
LP/J	MGP_LPJ_G0023715	protein coding gene	Chr17:47920247-47966437 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023630	protein coding gene	Chr17:50624976-50667512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024256	protein coding gene	Chr17:46797757-46840207 (+)
PWK/PhJ	MGP_PWKPhJ_G0022758	protein coding gene	Chr17:44220480-44259375 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022573	protein coding gene	Chr17:43699824-43739925 (+)
WSB/EiJ	MGP_WSBEiJ_G0023078	protein coding gene	Chr17:47350695-47390426 (+)

Human Ortholog

XPO5, exportin 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPO5, exportin 5
Synonyms

exp5
Links

HGNC:17675

NCBI Gene ID: 57510

neXtProt AC: NX_Q9HAV4

UniProt: Q9HAV4
Chr Location

6p21.1; chr6:43522334-43576038 (-) GRCh38

MGI Vertebrate Homology

Xpo5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: XPO5
Gene Tree

Xpo5

Diseases

7 with human XPO5 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				lung small cell carcinoma IDs lung small cell carcinoma DOID:5409 KEGG:05222 MESH:D055752 NCI:C4917 OMIM:182280 UMLS_CUI:C0149925
				multiple myeloma IDs multiple myeloma DOID:9538 EFO:0001378 ICD10CM:C90.0 ICD9CM:203.0 MESH:D009101 NCI:C3242 OMIM:254500 ORDO:29073 UMLS_CUI:C0026764
				primary ovarian insufficiency IDs primary ovarian insufficiency DOID:5426 ICD10CM:E28.3 MESH:D016649 NCI:C113352 OMIM:PS311360 ORDO:619 UMLS_CUI:C0085215

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

3
Gene trapped

14
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

3
cDNA Data

230
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA XPO5

Xenbase xpo5, xpo5.2

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All Sequences

49
RefSeq

2
UniProt

4
CCDS

CCDS37631.1

Ensembl

ENSMUSG00000067150 (Evidence)
NCBI Gene

72322

			Length	Strain/Species	Flank
genomic	72322	NCBI Gene Model \| MGI Sequence Detail	40788	C57BL/6J	± kb
transcript	NM_028198	RefSeq \| MGI Sequence Detail	5052	C57BL/6
polypeptide	Q924C1	UniProt \| EBI \| MGI Sequence Detail	1204	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000017499 exportin-5

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR045065 Exportin-1/5

IPR013598 Exportin-1/Importin-beta-like

IPR045478 Exportin-5, C-terminal domain

IPR001494 Importin-beta, N-terminal domain
GlyGen

Q924C1 1 site, 1 N-linked glycan (1 site)

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All nucleic 231

cDNA 230

Primer pair 1

Microarray probesets 5

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MGI:1919572, MGI:2146903, MGI:2147079

Summaries

All 39

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Xpo5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144831	Chr17:46513666-46513780 (+)	-14 bp
Tssr144832	Chr17:46513787-46513804 (+)	59 bp
Tssr144833	Chr17:46538696-46538706 (+)	24,964 bp
Tssr144834	Chr17:46538714-46538725 (+)	24,983 bp
Tssr144835	Chr17:46538729-46538734 (+)	24,995 bp
Tssr144836	Chr17:46538753-46538756 (+)	25,018 bp
Tssr144837	Chr17:46538795-46538796 (+)	25,059 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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