Adamtsl5 MGI Mouse Gene Detail - MGI:1913798

Symbol

Adamtsl5
Name

ADAMTS-like 5
Synonyms

2010109H09Rik, Thsd6

Feature Type

protein coding gene
IDs

MGI:1913798
NCBI Gene: 66548
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:80175655-80184246 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913798	protein coding gene	Chr10:80174944-80184246 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017498	protein coding gene	Chr10:80940570-80950727 (-)
A/J	MGP_AJ_G0017476	protein coding gene	Chr10:78105832-78116284 (-)
AKR/J	MGP_AKRJ_G0017437	protein coding gene	Chr10:80244350-80256806 (-)
BALB/cJ	MGP_BALBcJ_G0017438	protein coding gene	Chr10:78335324-78345325 (-)
C3H/HeJ	MGP_C3HHeJ_G0017261	protein coding gene	Chr10:80336637-80347044 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017892	protein coding gene	Chr10:83742937-83754172 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015580	protein coding gene	Chr10:74326360-74335176 (-)
CAST/EiJ	MGP_CASTEiJ_G0016828	protein coding gene	Chr10:80543699-80558724 (-)
CBA/J	MGP_CBAJ_G0017233	protein coding gene	Chr10:86976120-86991449 (-)
DBA/2J	MGP_DBA2J_G0017339	protein coding gene	Chr10:77323668-77333559 (-)
FVB/NJ	MGP_FVBNJ_G0017333	protein coding gene	Chr10:76515705-76525323 (-)
LP/J	MGP_LPJ_G0017410	protein coding gene	Chr10:81409982-81421202 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017359	protein coding gene	Chr10:88924221-88937659 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017933	protein coding gene	Chr10:80229973-80240452 (-)
PWK/PhJ	MGP_PWKPhJ_G0016609	protein coding gene	Chr10:77194849-77204210 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016398	protein coding gene	Chr10:79201125-79211902 (-)
WSB/EiJ	MGP_WSBEiJ_G0016888	protein coding gene	Chr10:80262954-80272956 (-)

Human Ortholog

ADAMTSL5, ADAMTS like 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADAMTSL5, ADAMTS like 5
Synonyms

THSD6
Links

HGNC:27912

NCBI Gene ID: 339366

neXtProt AC: NX_Q6ZMM2

UniProt: Q6ZMM2
Chr Location

19p13.3; chr19:1505022-1513604 (-) GRCh38

MGI Vertebrate Homology

Adamtsl5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADAMTSL5
Gene Tree

Adamtsl5

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Adamtsl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

66
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC100379976

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All Sequences

57
RefSeq

11
UniProt

3
CCDS

CCDS24019.1, CCDS48628.1

Ensembl

ENSMUSG00000043822 (Evidence)
NCBI Gene

66548

			Length	Strain/Species	Flank
genomic	66548	NCBI Gene Model \| MGI Sequence Detail	8592	C57BL/6J	± kb
transcript	NR_104339	RefSeq \| MGI Sequence Detail	3494	C57BL/6
polypeptide	NP_001272364	RefSeq \| MGI Sequence Detail	485	C57BL/6

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UniProt

3 Sequences
InterPro Domains

IPR013273 ADAMTS/ADAMTS-like

IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3

IPR010294 ADAMTS/ADAMTS-like, Spacer 1

IPR050439 ADAMTS and ADAMTS-like

IPR001134 Netrin domain

IPR018933 Netrin module, non-TIMP type

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily

IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold

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All nucleic 14

cDNA 12

Primer pair 2

Microarray probesets 5

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Adamtsl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98438	Chr10:80184833-80184865 (-)	-603 bp
Tssr98437	Chr10:80184451-80184497 (-)	-228 bp
Tssr98436	Chr10:80184421-80184445 (-)	-187 bp
Tssr98435	Chr10:80184266-80184292 (-)	-33 bp
Tssr98434	Chr10:80184239-80184252 (-)	0 bp
Tssr98433	Chr10:80184191-80184201 (-)	50 bp
Tssr98432	Chr10:80181048-80181094 (-)	3,175 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24