Crls1 MGI Mouse Gene Detail - MGI:1913836

Symbol

Crls1
Name

cardiolipin synthase 1
Synonyms

0610009I22Rik, 4930557M15Rik, 5730490M08Rik

Feature Type

protein coding gene
IDs

MGI:1913836
NCBI Gene: 66586
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:132688586-132708705 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 64.77 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

632 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913836	protein coding gene	Chr2:132688557-132708706 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026548	protein coding gene	Chr2:136475999-136497957 (+)
A/J	MGP_AJ_G0026512	protein coding gene	Chr2:130905152-130926086 (+)
AKR/J	MGP_AKRJ_G0026486	protein coding gene	Chr2:134694124-134714991 (+)
BALB/cJ	MGP_BALBcJ_G0026524	protein coding gene	Chr2:131312830-131333841 (+)
C3H/HeJ	MGP_C3HHeJ_G0026267	protein coding gene	Chr2:135131146-135151260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026969	protein coding gene	Chr2:140625321-140647127 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024346	protein coding gene	Chr2:125629729-125652062 (+)
CAST/EiJ	MGP_CASTEiJ_G0025728	protein coding gene	Chr2:135469961-135490235 (+)
CBA/J	MGP_CBAJ_G0026247	protein coding gene	Chr2:145902032-145922197 (+)
DBA/2J	MGP_DBA2J_G0026381	protein coding gene	Chr2:130291020-130311011 (+)
FVB/NJ	MGP_FVBNJ_G0026345	protein coding gene	Chr2:128923892-128943878 (+)
LP/J	MGP_LPJ_G0026485	protein coding gene	Chr2:136705287-136726493 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026365	protein coding gene	Chr2:149620750-149641915 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027024	protein coding gene	Chr2:134656786-134676815 (+)
PWK/PhJ	MGP_PWKPhJ_G0025464	protein coding gene	Chr2:129907308-129928061 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025266	protein coding gene	Chr2:133817638-133842520 (+)
WSB/EiJ	MGP_WSBEiJ_G0025802	protein coding gene	Chr2:135578082-135601854 (+)

Human Ortholog

CRLS1, cardiolipin synthase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRLS1, cardiolipin synthase 1
Synonyms

C20orf155, CLS, CLS1, COSPD57, dJ967N21.6, GCD10
Links

HGNC:16148

NCBI Gene ID: 54675

neXtProt AC: NX_Q9UJA2

UniProt: Q9UJA2
Chr Location

20p12.3; chr20:6005938-6040053 (+) GRCh38

MGI Vertebrate Homology

Crls1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRLS1
Protein SuperFamily

Phos_ph_gly_syn
Gene Tree

Crls1

Diseases

1 with human CRLS1 associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 57 IDs combined oxidative phosphorylation deficiency 57 DOID:0070430 OMIM:620167

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 2 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Crls1
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit defects in chorion and trophoblast layer formation and complete lethality throughout fetal growth and development.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

95
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase crls1

ZFIN crls1

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All Sequences

54
RefSeq

7
UniProt

5
CCDS

CCDS16779.1, CCDS38247.1

Ensembl

ENSMUSG00000027357 (Evidence)
NCBI Gene

66586

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027357	Ensembl Gene Model \| MGI Sequence Detail	20120	C57BL/6J	± kb
transcript	ENSMUST00000028835	Ensembl \| MGI Sequence Detail	1924	Not Applicable
polypeptide	ENSMUSP00000028835	Ensembl \| MGI Sequence Detail	303	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005888 CMP-forming cardiolipin synthase

(term hierarchy)
EC

2.7.8.41
InterPro Domains

IPR000462 CDP-alcohol phosphatidyltransferase

IPR050324 CDP-alcohol phosphatidyltransferase class-I

IPR043130 CDP-alcohol phosphatidyltransferase, transmembrane domain

IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

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All nucleic 15

cDNA 12

Primer pair 2

Other 1

Microarray probesets 7

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MGI:1917885, MGI:1922621

Summaries

All 46

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crls1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20338	Chr2:132688558-132688628 (+)	7 bp
Tssr20339	Chr2:132688770-132688774 (+)	186 bp
Tssr20340	Chr2:132688825-132688871 (+)	262 bp
Tssr20341	Chr2:132689627-132689636 (+)	1,046 bp
Tssr20342	Chr2:132689639-132689663 (+)	1,065 bp
Tssr20343	Chr2:132689739-132689751 (+)	1,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24