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Nsmce3 Gene Detail
Summary
  • Symbol
    Nsmce3
  • Name
    NSE3 homolog, SMC5-SMC6 complex component
  • Synonyms
    5730494G16Rik, HCA4, Mageg1, Ndnl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913897
    NCBI Gene: 66647
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:64521430-64522788 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 34.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913897
 protein coding gene Chr7:64516800-64522788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032341
 protein coding gene Chr7:66020857-66026798 (-)
A/J MGP_AJ_G0032320
 protein coding gene Chr7:64699445-64705386 (-)
AKR/J MGP_AKRJ_G0032256
 protein coding gene Chr7:66070649-66076590 (-)
BALB/cJ MGP_BALBcJ_G0032332
 protein coding gene Chr7:64437601-64443542 (-)
C3H/HeJ MGP_C3HHeJ_G0032045
 protein coding gene Chr7:66742270-66748211 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032825
 protein coding gene Chr7:68889306-68895251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029832
 protein coding gene Chr7:67629946-67635638 (-)
CAST/EiJ MGP_CASTEiJ_G0031374
 protein coding gene Chr7:57408076-57414031 (-)
CBA/J MGP_CBAJ_G0032011
 protein coding gene Chr7:71044118-71050059 (-)
DBA/2J MGP_DBA2J_G0032167
 protein coding gene Chr7:63438566-63444538 (-)
FVB/NJ MGP_FVBNJ_G0032121
 protein coding gene Chr7:63552041-63557988 (-)
LP/J MGP_LPJ_G0032247
 protein coding gene Chr7:67261688-67267635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032158
 protein coding gene Chr7:71324929-71330870 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032842
 protein coding gene Chr7:65414995-65420942 (-)
PWK/PhJ MGP_PWKPhJ_G0031094
 protein coding gene Chr7:56464436-56470811 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030935
 protein coding gene Chr7:52492435-52497870 (-)
WSB/EiJ MGP_WSBEiJ_G0031492
 protein coding gene Chr7:65753782-65759727 (-)



Homology
more
  • Human Ortholog
    NSMCE3, NSE3 homolog, SMC5-SMC6 complex component
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NSMCE3, NSE3 homolog, SMC5-SMC6 complex component
  • Synonyms
    HCA4, LICS, MAGEG1, MAGEL3, NDNL2, NSE3
  • Links
    NCBI Gene ID: 56160
    neXtProt AC: NX_Q96MG7
    UniProt: Q96MG7

  • Chr Location
    15q13.1; chr15:29264989-29269822 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Nsmce3
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    8 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    50
  • cDNA Data
    54
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66647 NCBI Gene Model | MGI Sequence Detail 1359 C57BL/6J ±  kb
transcript NM_023239 RefSeq | MGI Sequence Detail 1359 C57BL/6  
polypeptide Q9CPR8 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR002190 MAGE homology domain
    IPR041898 MAGE homology domain, winged helix WH1 motif
    IPR041899 MAGE homology domain, winged helix WH2 motif
    IPR037445 Melanoma-associated antigen
  • GlyGen
    Q9CPR8 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 56
    cDNA 54
    Primer pair 1
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2142015, MGI:2142279
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory