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Brf2 Gene Detail
Summary
  • Symbol
    Brf2
  • Name
    BRF2, RNA polymerase III transcription initiation factor 50kDa subunit
  • Synonyms
    2700059M06Rik, 5730512K07Rik, BRFU, TFIIIB50
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913903
    NCBI Gene: 66653
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27613392-27618708 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 15.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913903
 protein coding gene Chr8:27613367-27618743 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033502
 protein coding gene Chr8:25311451-25316251 (-)
A/J MGP_AJ_G0033482
 protein coding gene Chr8:24342658-24347458 (-)
AKR/J MGP_AKRJ_G0033407
 protein coding gene Chr8:25146600-25151387 (-)
BALB/cJ MGP_BALBcJ_G0033478
 protein coding gene Chr8:24501754-24506554 (-)
C3H/HeJ MGP_C3HHeJ_G0033192
 protein coding gene Chr8:25368250-25373043 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033994
 protein coding gene Chr8:26289993-26294793 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030944
 protein coding gene Chr8:21594416-21599027 (-)
CAST/EiJ MGP_CASTEiJ_G0032518
 protein coding gene Chr8:24855728-24860524 (-)
CBA/J MGP_CBAJ_G0033167
 protein coding gene Chr8:27328381-27333181 (-)
DBA/2J MGP_DBA2J_G0033322
 protein coding gene Chr8:24308565-24313804 (-)
FVB/NJ MGP_FVBNJ_G0033266
 protein coding gene Chr8:24121433-24127980 (-)
LP/J MGP_LPJ_G0033411
 protein coding gene Chr8:25263583-25268383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033309
 protein coding gene Chr8:26769333-26774189 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034013
 protein coding gene Chr8:25130737-25135539 (-)
PWK/PhJ MGP_PWKPhJ_G0032229
 protein coding gene Chr8:23968515-23975941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032063
 protein coding gene Chr8:24516734-24521519 (-)
WSB/EiJ MGP_WSBEiJ_G0032634
 protein coding gene Chr8:25314666-25319470 (-)



Homology
more
  • Human Ortholog
    BRF2, BRF2 general transcription factor IIIB subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRF2, BRF2 general transcription factor IIIB subunit
  • Synonyms
    BRFU, TFIIIB50
  • Links
    NCBI Gene ID: 55290
    neXtProt AC: NX_Q9HAW0
    UniProt: Q9HAW0

  • Chr Location
    8p11.23; chr8:37843268-37849861 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031487 Ensembl Gene Model | MGI Sequence Detail 5317 C57BL/6J ±  kb
transcript ENSMUST00000033877 Ensembl | MGI Sequence Detail 1899 Not Applicable  
polypeptide ENSMUSP00000033877 Ensembl | MGI Sequence Detail 420 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919827, MGI:2142684, MGI:2142706
References
more
  • Summaries
    All 31
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory